Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death

Kapralov Alexandr A.; Yang Qin; Dar Haider H.; Tyurina Yulia Y.; Anthonymuthu Tamil S.; Kim Rina; St Croix Claudette M.; Mikulska-Ruminska Karolina; Liu Bing; Shrivastava Indira H.; Tyurin Vladimir A.; Ting Hsiu-Chi; Wu Yijen L.; Gao Yuan; Shurin Galina V.; Artyukhova Margarita A.; Ponomareva Liubov A.; Timashev Peter S.; Domingues Rosario M.; Stoyanovsky Detcho A.; Greenberger Joel S.; Mallampalli Rama K.; Bahar Ivet; Gabrilovich Dmitry I.; Bayir Hulya; Kagan Valerian E.

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Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death

机译：氧化还原脂质重新编程命令巨噬细胞和小胶质细胞对硬化死亡的易感性

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Susceptibility to ferroptosis can be modulated by nitric oxide (NO center dot) and NO synthase iNOS and through enrichment of activated M1 macrophages. NO inhibits the lipoxygenase 15-LOX that drives production of pro-ferroptotic lipids in macrophages.

机译：对硬质裂化的易感性可以通过一氧化氮（无中心点）和没有合成酶InOS来调节，并通过富集活性的M1巨噬细胞。不抑制脂氧酶15-LOX，其在巨噬细胞中驱动生产的Pro-Ferropotics脂质。

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来源
《Nature chemical biology》 |2020年第3期|共17页
作者
Kapralov Alexandr A.; Yang Qin; Dar Haider H.; Tyurina Yulia Y.; Anthonymuthu Tamil S.; Kim Rina; St Croix Claudette M.; Mikulska-Ruminska Karolina; Liu Bing; Shrivastava Indira H.; Tyurin Vladimir A.; Ting Hsiu-Chi; Wu Yijen L.; Gao Yuan; Shurin Galina V.; Artyukhova Margarita A.; Ponomareva Liubov A.; Timashev Peter S.; Domingues Rosario M.; Stoyanovsky Detcho A.; Greenberger Joel S.; Mallampalli Rama K.; Bahar Ivet; Gabrilovich Dmitry I.; Bayir Hulya; Kagan Valerian E.;
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作者单位

Univ Pittsburgh Dept Environm &

Occupat Hlth Pittsburgh PA 15260 USA;

Univ Pittsburgh Childrens Hosp Pittsburgh Childrens Neurosci Inst Dept Crit Care Med Safar Ctr Resuscitat Res Pittsburgh PA 15213 USA;

Univ Pittsburgh Dept Environm &

Occupat Hlth Pittsburgh PA 15260 USA;

Univ Pittsburgh Dept Environm &

Occupat Hlth Pittsburgh PA 15260 USA;

Univ Pittsburgh Childrens Hosp Pittsburgh Childrens Neurosci Inst Dept Crit Care Med Safar Ctr Resuscitat Res Pittsburgh PA 15213 USA;

Wistar Inst Anat &

Biol 3601 Spruce St Philadelphia PA 19104 USA;

Univ Pittsburgh Dept Cell Biol Pittsburgh PA USA;

Univ Pittsburgh Dept Computat &

Syst Biol Pittsburgh PA USA;

Univ Pittsburgh Dept Computat &

Syst Biol Pittsburgh PA USA;

Univ Pittsburgh Dept Environm &

Occupat Hlth Pittsburgh PA 15260 USA;

Univ Pittsburgh Dept Environm &

Occupat Hlth Pittsburgh PA 15260 USA;

Univ Pittsburgh Dept Environm &

Occupat Hlth Pittsburgh PA 15260 USA;

Univ Pittsburgh Childrens Hosp Pittsburgh Rangos Res Ctr Dept Dev Biol Pittsburgh PA 15213 USA;

Univ Pittsburgh Childrens Hosp Pittsburgh Childrens Neurosci Inst Dept Crit Care Med Safar Ctr Resuscitat Res Pittsburgh PA 15213 USA;

Univ Pittsburgh Dept Environm &

Occupat Hlth Pittsburgh PA 15260 USA;

Univ Pittsburgh Dept Environm &

Occupat Hlth Pittsburgh PA 15260 USA;

Univ Pittsburgh Dept Environm &

Occupat Hlth Pittsburgh PA 15260 USA;

IM Sechenov Moscow State Med Univ Inst Regenerat Med Lab Nav Redox Lipid Moscow Russia;

Univ Aveiro Mass Spectrometry Ctr QOPNA Aveiro Portugal;

Univ Pittsburgh Dept Environm &

Occupat Hlth Pittsburgh PA 15260 USA;

Univ Pittsburgh Dept Radiat Oncol Pittsburgh PA 15260 USA;

Ohio State Univ Dept Internal Med Columbus OH 43210 USA;

Univ Pittsburgh Dept Computat &

Syst Biol Pittsburgh PA USA;

Wistar Inst Anat &

Biol 3601 Spruce St Philadelphia PA 19104 USA;

Univ Pittsburgh Dept Environm &

Occupat Hlth Pittsburgh PA 15260 USA;

Univ Pittsburgh Dept Environm &

Occupat Hlth Pittsburgh PA 15260 USA;

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正文语种 eng
中图分类生物化学;
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1. Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death [J] . Kapralov Alexandr A., Yang Qin, Dar Haider H., Nature chemical biology . 2020,第3期

机译：氧化还原脂质重新编程命令巨噬细胞和小胶质细胞对硬化死亡的易感性
2. Apolipoprotein E receptor-2 deficiency enhances macrophage susceptibility to lipid accumulation and cell death to augment atherosclerotic plaque progression and necrosis [J] . WaltmannM.D., BasfordJ.E., KonaniahE.S., Biochimica et biophysica acta. Molecular basis of disease: BBA . 2014,第9期

机译：载脂蛋白E受体2缺乏症增强了巨噬细胞对脂质积累和细胞死亡的敏感性，从而加剧了动脉粥样硬化斑块的进展和坏死
3. Anticancer efficacy of noble metal nanoparticles relies on reprogramming tumor-associated macrophages through redox pathways and pro-inflammatory cytokine cascades [J] . Mahuya Sengupta, Ramkrishna Pal, Anupam Nath, 细胞与分子免疫学：英文版 . 2018,第012期

机译：贵金属纳米粒子的抗癌疗效依赖于通过氧化还原途径和促炎细胞因子级联重编程肿瘤相关巨噬细胞
4. Identification and quantification of oxygenated arachidonoyl- and adrenoyl-phosphatidylethanolamines as ferroptotic death signals using oxidative phospholipidomics [C] . Yulia Tyurina, Andrew Amoscato, Vladimir Tyurin, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：使用氧化磷脂族鉴定和定量含氧的甘蔗酰基和亚辛酰基磷脂酰乙醇胺作为糖凋亡死亡信号
5. Annexin A2 and microglia/macrophages in glioma progression. [D] . Zhai, Haiyan. 2010

机译：胶质瘤进展中的膜联蛋白A2和小胶质细胞/巨噬细胞。
6. Apolipoprotein E receptor-2 deficiency enhances macrophage susceptibility to lipid accumulation and cell death to augment atherosclerotic plaque progression and necrosis [O] . Meaghan D. Waltmann, Joshua E. Basford, Eddy S. Konaniah, -1

机译：载脂蛋白E受体2缺乏症增强了巨噬细胞对脂质积累和细胞死亡的敏感性从而加剧了动脉粥样硬化斑块的进展和坏死
7. Apolipoprotein E receptor-2 deficiency enhances macrophage susceptibility to lipid accumulation and cell death to augment atherosclerotic plaque progression and necrosis [O] . Waltmann Meaghan D., Basford Joshua E., Konaniah Eddy S., 2014

机译：载脂蛋白E受体2缺乏症增强了巨噬细胞对脂质积累和细胞死亡的敏感性，从而加剧了动脉粥样硬化斑块的进展和坏死

Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death

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