A New Limonoid from Chisocheton paniculatus Fruit Collected in Vietnam and Its NO Production Inhibitory Activity

摘要

A new limonoid, 6 alpha,7 alpha-diacetoxy-3-oxo-24,25,26,27-tetranorapotirucalla-1,14,20(22)-trien-21,23-lactam (1), was isolated from the fruits of Chisocheton paniculatus Hiern collected in Vietnam, together with two known 5 alpha,8 alpha-epidioxysterols, (22E,24R)-5 alpha,8 alpha-epidioxy-24-methyl-cholesta-6,22-dien-3 beta-ol (2) and (22E,24R)-5 alpha,8 alpha-epidioxy-24-methyl-cholesta-6,9(11),22-trien-3 beta-ol (3). Their structures were elucidated by spectroscopic analyses, including 1D- and 2D-NMR and HRESIMS, and comparisons with the reported data in the literature. Compounds 1-3 exhibited the NO production inhibitory activities against the LPS stimulated BV2 cells with 69.0 +/- 2.7 %, 69.5 +/- 2.2 %, and 70.6 +/- 1.6 %, at concentration of 20.0 mu M, respectively.