A Strategy for Microwave-Controlled Release of Anticancer Drugs: (Fe3O4/nGO)@mSiO(2)/GQDs Nanocomposite Carrier Jointly Enhanced by nGO and GQDs

摘要

We constructed a multifunctional (Fe3O4/nGO)@mSiO(2)/GQDs drug carrier for loading and microwave-controlled release of an etoposide (VP16) as the anticancer drug. This nanocomposite consisted of magnetic core Fe3O4, microwave-absorbing nanographene oxide (nGO), fluorescent graphene quantum dots (GQDs) and intermediate barrier layer (mesoporous silica). It has a large surface area of 359.8 m(2)/g, excellent fluorescence emission and ample magnetic performance of 36.00 emu/g. After microwave irradiation for 140 s, the temperature of (Fe3O4/nGO)@mSiO(2)/GQDs nanoparticles rapidly went up to 90 degrees C. The loading rate of VP16 was as high as 68%, the release rate reached 87% within 280 min under microwave irradiation. Therefore, the functionalized (Fe3O4/nGO)@mSiO(2)/GQDs nanoparticles will have potential application for clinical treatment as drug delivery system.