Intermittent Theta-burst Stimulation Rescues Dopamine-Dependent Corticostriatal Synaptic Plasticity and Motor Behavior in Experimental Parkinsonism: Possible Role of Glial Activity

摘要

Background: Recent studies support the therapeutic utility of repetitive transcranial magnetic stimulation in Parkinson's disease (PD), whose progression is correlated with loss of corticostriatal long-term potentiation and long-term depression. Glial cell activation is also a feature of PD that is gaining increasing attention in the field because astrocytes play a role in chronic neuroinflammatory responses but are also able to manage dopamine (DA) levels.