High mRNA levels of 17 beta-hydroxysteroid dehydrogenase type 1 correlate with poor prognosis in endometrial cancer

Cornel Karlijn M. C.; Krakstad Camilla; Delvoux Bert; Xanthoulea Sofia; Jori Balazs; Bongers Marlies Y.; Konings Gonda F. J.; Kooreman Loes F. S.; Kruitwagen Roy F. P. M.; Salvesen Helga B.; Romano Andrea

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High mRNA levels of 17 beta-hydroxysteroid dehydrogenase type 1 correlate with poor prognosis in endometrial cancer

机译：17β-羟类脱氢酶1的高mRNA水平1与子宫内膜癌的预后不良相关

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Most endometrial cancers (ECs) are diagnosed at an early stage and have a good prognosis. However, 20-30% develop recurrence and have poor survival. Recurrence-risk prediction at diagnosis is hampered by the scarcity of prognostic markers.

机译：大多数子宫内膜癌症（ECS）被诊断为早期阶段并且具有良好的预后。然而，20-30％的发育复发并存活不足。诊断的复发风险预测因预后标志物的稀缺而受到阻碍。

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来源
《Molecular and Cellular Endocrinology 》 |2017年第2017期| 共7页
作者
Cornel Karlijn M. C.; Krakstad Camilla; Delvoux Bert; Xanthoulea Sofia; Jori Balazs; Bongers Marlies Y.; Konings Gonda F. J.; Kooreman Loes F. S.; Kruitwagen Roy F. P. M.; Salvesen Helga B.; Romano Andrea;
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作者单位

Maastricht Univ Med Ctr Dept Obstet &

Gynaecol GROW Sch Oncol &

Dev Biol P Debyelaan 25 NL;

Univ Bergen Dept Biomed Ctr Canc Biomarkers N-5020 Bergen Norway;

Maastricht Univ Med Ctr Dept Obstet &

Gynaecol GROW Sch Oncol &

Dev Biol P Debyelaan 25 NL;

Maastricht Univ Med Ctr Dept Obstet &

Gynaecol GROW Sch Oncol &

Dev Biol P Debyelaan 25 NL;

Maastricht Univ Med Ctr Dept Obstet &

Gynaecol GROW Sch Oncol &

Dev Biol P Debyelaan 25 NL;

Maastricht Univ Med Ctr Dept Obstet &

Gynaecol GROW Sch Oncol &

Dev Biol P Debyelaan 25 NL;

Maastricht Univ Med Ctr Dept Obstet &

Gynaecol GROW Sch Oncol &

Dev Biol P Debyelaan 25 NL;

Maastricht Univ Med Ctr Dept Obstet &

Gynaecol GROW Sch Oncol &

Dev Biol P Debyelaan 25 NL;

Univ Bergen Dept Biomed Ctr Canc Biomarkers N-5020 Bergen Norway;

Maastricht Univ Med Ctr Dept Obstet &

Gynaecol GROW Sch Oncol &

Dev Biol P Debyelaan 25 NL;

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原文格式 PDF
正文语种 eng
中图分类内分泌腺疾病及代谢病 ;
关键词
Endometrial cancer; 17 beta-hydroxysteroid-dehydrogenase-type 1; 17 beta-hydroxysteroid-dehydrogenase-type 2; Steroid sulphatase; Estrogen-sulphotransferase; Aromatase; Estrogens; Prognosis;

机译：子宫内膜癌;17β-羟类雌激素 - 脱氢酶型1;17β-羟类雌激素 - 脱氢酶 - 2型;类固醇硫酸盐酶;雌激素 - 硫酸转移酶;芳香酶;雌激素;预后;预后;

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专利

1. High mRNA levels of 17 beta-hydroxysteroid dehydrogenase type 1 correlate with poor prognosis in endometrial cancer [J] . Cornel Karlijn M. C., Krakstad Camilla, Delvoux Bert, Molecular and Cellular Endocrinology . 2017 ,第期

机译：17β-羟类脱氢酶1的高mRNA水平1与子宫内膜癌的预后不良相关
2. Regulation of cytochrome P450 cholesterol side-chain cleavage, 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase type 1 and estradiol-17 beta-hydroxysteroid dehydrogenase mRNA levels by calcium in human choriocarcinoma JEG-3 cells. [J] . Beaudoin C, Bonenfant M, Tremblay Y Molecular and Cellular Endocrinology . 1997 ,第1期

机译：钙调节人绒毛膜癌JEG-3细胞中细胞色素P450胆固醇侧链的裂解，3型β-羟基类固醇脱氢酶/δ5δ4型异构酶和雌二醇17β-羟基类固醇脱氢酶mRNA的水平。
3. Blocking 17 beta-hydroxysteroid dehydrogenase type 1 in endometrial cancer: a potential novel endocrine therapeutic approach [J] . Konings Gonda F. J., Cornel Karlijn M. C., Xanthoulea Sofia, Journal of Pathology: Journal of the Pathological Society of Great Britain and Ireland . 2018 ,第2期

机译：在子宫内膜癌中阻断17β-羟类脱氢酶1型：潜在的新型内分泌治疗方法
4. Sperm protein 17 highly expressed in endometrial and cervical cancers [C] . Li Fang-Qiu, Liu Qun, Han Yan-Ling, International Symposium on Medical and Pharmaceutical Biotechnology(医药生物技术国际研讨会) . 2009

机译：在子宫内膜和宫颈癌中高表达的精子蛋白17
5. Single-nucleotide polymorphisms in 17beta-hydroxysteroid dehydrogenase type III and prostate cancer risk. [D] . Kim, Eugene. 2003

机译：17β-羟类固醇脱氢酶III型中的单核苷酸多态性和前列腺癌的风险。
6. 17β hydroxysteroid dehydrogenase type 12 (HSD17B12) is a marker of poor prognosis in ovarian carcinoma [O] . Marta Szajnik, Miroslaw J. Szczepanski, Esther Elishaev, -1

机译：17β羟类脱氢酶12（HSD17B12）是卵巢癌预后不良的标志物
7. Estrogen and androgen-converting enzymes 17 beta-hydroxysteroid dehydrogenase and their involvement in cancer: with a special focus on 17 beta-hydroxysteroid dehydrogenase type 1, 2, and breast cancer [O] . Hilborn, Erik, Stål, Olle, Jansson, Agneta 2017

机译：雌激素和雄激素转化酶17β-羟基类固醇脱氢酶及其与癌症的关系：特别关注17型β-羟基类固醇脱氢酶1、2和乳腺癌

High mRNA levels of 17 beta-hydroxysteroid dehydrogenase type 1 correlate with poor prognosis in endometrial cancer

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