Aberrant expression of Wnt/beta-catenin signaling pathway genes in aggressive malignant gastric gastrointestinal stromal tumors

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Aberrant expression of Wnt/beta-catenin signaling pathway genes in aggressive malignant gastric gastrointestinal stromal tumors

机译：WNT /β - catenin信号传导途径基因在激进恶性胃肠胃肠胃肠肿瘤中的异常表达

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Introduction: Recent reports on gene expression profiling (GEP) show several genes associated with malignant progression of GIST. However, genes associated with malignant transformation have not been clarified. Here, we aimed to reveal distinct genes in aggressive malignant GIST, using comprehensive gene expression analysis.

机译：介绍：最近关于基因表达分析（GEP）的报告显示了与GIST的恶性进展相关的几个基因。然而，尚未澄清与恶性转化相关的基因。在这里，我们旨在利用综合基因表达分析揭示侵袭性恶性剂中不同的基因。

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《European Journal of Surgical Oncology: The Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology》 |2020年第6期|共8页
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正文语种 eng
中图分类肿瘤学;
关键词
beta-catenin; FZD; Gene expression profiling; Malignant GIST; Wnt pathway;

机译：Beta-catenin;FZD;基因表达谱;恶性GIST;WNT途径;

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1. Aberrant expression of Wnt/beta-catenin signaling pathway genes in aggressive malignant gastric gastrointestinal stromal tumors [J] . European Journal of Surgical Oncology: The Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology . 2020,第6期

机译：WNT /β - catenin信号传导途径基因在激进恶性胃肠胃肠胃肠肿瘤中的异常表达
2. Constitutive expression of PPAR gamma inhibits proliferation and migration of gastric cancer cells and down-regulates Wnt/beta-Catenin signaling pathway downstream target genes TERT and ENAH [J] . Guo Fang, Ren Xiyun, Dong Yingzi, Gene: An International Journal Focusing on Gene Cloning and Gene Structure and Function . 2016,第1期

机译：PPARγ的本构表达抑制胃癌细胞的增殖和迁移并下调Wnt /β-Catenin信号通路下游靶基因TERT和ENAH
3. Driver gene alterations and activated signaling pathways toward malignant progression of gastrointestinal stromal tumors [J] . Keiichi Ohshima, Keiichi Fujiya, Takeshi Nagashima, Cancer science. . 2019,第12期

机译：驾驶员基因改变和激活的信号通路朝向胃肠道间质瘤的恶性进展
4. A Case of Multiple Gastrointestinal Stromal Tumor Confirmed by Immunostaining for the Resected Material of Gastric Cancer [C] . H. Hashida, K. Komuro, N. Iwashiro, International College of Surgeons . 2006

机译：通过对切除的胃癌材料进行免疫染料证实了多种胃肠道基质肿瘤的情况
5. Targeting determinants of aggressiveness in malignant brain tumors: the role of hDRR-1 in glioma invasion and Wnt signaling in medulloblastoma biology. [D] . de Oliveira, Roberta. 2010

机译：针对恶性脑肿瘤侵袭性的目标决定因素：hDRR-1在神经胶质瘤侵袭中的作用和髓母细胞瘤生物学中的Wnt信号传导。
6. ETV4 collaborates with Wnt/β-catenin signaling to alter cell cycle activity and promote tumor aggressiveness in gastrointestinal stromal tumor [O] . Shan Zeng, Adrian M. Seifert, Jennifer Q. Zhang, 2017

机译：ETV4与Wnt /β-catenin信号传导合作改变细胞周期活性并促进胃肠道间质瘤的肿瘤侵袭性
7. Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis. [O] . Kolligs, Frank T, Bommer, Guido, Göke, Burkhard 2002

机译：Wnt /β-catenin/ tcf信号传导：胃肠道肿瘤发生的关键途径。
8. Analysis of the Role of the Wnt/Beta-Catenin Pathway in Prostate Development and Tumorigenesis [R] . Williams, B. O. 2006

机译：Wnt /β-Catenin通路在前列腺发育和肿瘤发生中的作用分析

Aberrant expression of Wnt/beta-catenin signaling pathway genes in aggressive malignant gastric gastrointestinal stromal tumors

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