BRAF(V600E) mutation as a predictor of thyroid malignancy in indeterminate nodules: A systematic review and meta-analysis

摘要

Background: Thyroid nodules are usually diagnosed using fine-needle aspiration (FNA). The sensitivity limitations of FNA result in 10-30% of nodules being classified as "indeterminate". The BRAF(V600E) mutation is associated with papillary thyroid carcinoma (PTC). We conducted a systemic review and meta-analysis to evaluate the diagnostic utility of the BRAF(V660E) mutation in indeterminate nodules.