Ventricular pro-arrhythmic phenotype, arrhythmic substrate, ageing and mitochondrial dysfunction in peroxisome proliferator activated receptor-gamma coactivator-1 beta deficient (Pgc-1 beta(-/-)) murine hearts

Ahmad Shiraz; Valli Haseeb; Chadda Karan R.; Cranley James; Jeevaratnam Kamalan; Huang Christopher L. -H.

首页> 外文期刊>Mechanisms of Ageing and Development >Ventricular pro-arrhythmic phenotype, arrhythmic substrate, ageing and mitochondrial dysfunction in peroxisome proliferator activated receptor-gamma coactivator-1 beta deficient (Pgc-1 beta(-/-)) murine hearts

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Ventricular pro-arrhythmic phenotype, arrhythmic substrate, ageing and mitochondrial dysfunction in peroxisome proliferator activated receptor-gamma coactivator-1 beta deficient (Pgc-1 beta(-/-)) murine hearts

机译：过氧化物体增殖物激活受体 - γ共粘膜-1β缺陷的心律失常促血液表型，心律失常底物，老化和线粒体功能障碍（PGC-1β（ - / - ））鼠心

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Introduction: Ageing and age-related bioenergetic conditions including obesity, diabetes mellitus and heart failure constitute clinical ventricular arrhythmic risk factors.

机译：介绍：衰老和年龄相关的生物能量条件包括肥胖，糖尿病和心力衰竭包括临床心律失常的风险因素。

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来源
《Mechanisms of Ageing and Development》 |2018年第2018期|共12页
作者
Ahmad Shiraz; Valli Haseeb; Chadda Karan R.; Cranley James; Jeevaratnam Kamalan; Huang Christopher L. -H.;
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作者单位

Univ Cambridge Physiol Lab Downing St Cambridge CB2 3EG England;

Univ Cambridge Physiol Lab Downing St Cambridge CB2 3EG England;

Univ Cambridge Physiol Lab Downing St Cambridge CB2 3EG England;

Univ Cambridge Physiol Lab Downing St Cambridge CB2 3EG England;

Univ Surrey Fac Hlth &

Med Sci Guildford GU2 7AL Surrey England;

Univ Cambridge Physiol Lab Downing St Cambridge CB2 3EG England;

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原文格式 PDF
正文语种 eng
中图分类人体生理学;
关键词
Ventricular arrhythmia; Mitochondrial dysfunction; Fibrosis; Peroxisome proliferator activated receptor-gamma; coactivator-1 (PGC-1); Action potential conduction;

机译：室性心律失常;线粒体功能障碍;纤维化;过氧化物血糖增殖剂活化受体 - γ;共粘膜-1（PGC-1）;动作电位传导;

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1. Ventricular pro-arrhythmic phenotype, arrhythmic substrate, ageing and mitochondrial dysfunction in peroxisome proliferator activated receptor-gamma coactivator-1 beta deficient (Pgc-1 beta(-/-)) murine hearts [J] . Ahmad Shiraz, Valli Haseeb, Chadda Karan R., Mechanisms of Ageing and Development . 2018,第期

机译：过氧化物体增殖物激活受体 - γ共粘膜-1β缺陷的心律失常促血液表型，心律失常底物，老化和线粒体功能障碍（PGC-1β（ - / - ））鼠心
2. Recruitment of RNA Polymerase II to Metabolic Gene Promoters Is Inhibited in the Failing Heart Possibly Through PGC-1 alpha ( Peroxisome Proliferator-Activated Receptor-gamma Coactivator-1 alpha) Dysregulation [J] . Bhat Santosh, Chin Adave, Shirakabe Akihiro, Circulation. Heart failure . 2019,第3期

机译：通过PGC-1α（过氧化物激素增殖物激活的受体 - γ-1α）失效，在失败的心脏中抑制了RNA聚合酶II至代谢基因启动子的募集
3. Carbohydrate Metabolism Is Perturbed in Peroxisome-deficient Hepatocytes Due to Mitochondrial Dysfunction, AMP-activated Protein Kinase (AMPK) Activation, and Peroxisome Proliferator-activated Receptor γ Coactivator 1α (PGC-1α) Suppression [J] . Annelies Peeters, Peter Fraisl, Sjoerd van den Berg, The Journal of biological chemistry . 2011,第49期

机译：由于线粒体功能障碍，AMP-活化的蛋白激酶（AMPK）活化和过氧化物体增殖物激活受体γ共粘膜1α（PGC-1α）抑制，碳水化合物代谢在过氧化物组血体缺乏肝细胞中扰乱了过氧化物组血缺乏肝细胞。（PGC-1α）抑制
4. Polymorphisms Scanning in of Egl Nine Homolog 3 and Peroxisome Proliferator Activated Receptor-alpha Genes in Tibetan and Lowland Chickens [C] . Cheng-Lin Zhong, Si-Chen Li, Jing-Jing Li, International Research Center for Animal Environment and Welfare;International Symposium on Animal Environment and Welfare;Chongqing Commussion of Society of Agricultural Engineering;China Agricultural University . -1

机译：藏九同源物3和过氧化物体增殖物激活受体 - α基因的多态性扫描藏和低地鸡
5. Modulation of skin cancer by peroxisome proliferator-activated receptor beta/delta. [D] . Bility, Moses Turkle. 2009

机译：过氧化物酶体增殖物激活的受体β/δ调节皮肤癌。
6. Ventricular pro-arrhythmic phenotype arrhythmic substrate ageing and mitochondrial dysfunction in peroxisome proliferator activated receptor-γ coactivator-1β deficient (Pgc-1β−/−) murine hearts [O] . Shiraz Ahmad, Haseeb Valli, Karan R. Chadda, -1

机译：过氧化物酶体增殖物激活受体-γ共激活因子-1β缺陷（Pgc-1β-/-）小鼠心脏的心律失常表型心律失常底物衰老和线粒体功能障碍
7. Ventricular pro-arrhythmic phenotype, arrhythmic substrate, ageing and mitochondrial dysfunction in peroxisome proliferator activated receptor-γ coactivator-1β deficient ( Pgc-1β −/− ) murine hearts [O] . Shiraz Ahmad, Haseeb Valli, Karan R. Chadda, 2018

机译：室性前心律学表型，心律失常底物，老化和线粒体功能障碍在过氧化物体增殖物激活受体-γ共觉器-1β缺陷（PGC-1β - / - ）鼠心

Ventricular pro-arrhythmic phenotype, arrhythmic substrate, ageing and mitochondrial dysfunction in peroxisome proliferator activated receptor-gamma coactivator-1 beta deficient (Pgc-1 beta(-/-)) murine hearts

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