ATR‐FTIR spectroscopy and μ‐EDXRF spectrometry monitoring of enamel erosion caused by medicaments used in the treatment of respiratory diseases

Gomes Raimundo Nonato Silva; Bhattacharjee Tanmoy T.; Carvalho Luis Felipe C. S.; Soares Luís Eduardo Silva; Mao Chuanbin

摘要

Abstract > Medicaments essential for alleviation of diseases may sometime adversely affect dental health by eroding the enamel, owing to their acidic nature. It is therefore highly desirable to be able to detect these effects quickly and reliably. In this study, we evaluated the erosive capacity of four most commonly prescribed respiratory disease syrup medicaments on enamel using micro‐energy‐dispersive X‐ray fluorescence spectrometry (μ‐EDXRF) and attenuated total reflection Fourier transform infrared spectroscopy (ATR‐FTIR). Fifty‐five enamel fragments obtained from 30 bovine teeth were treated with artificial saliva (S), acebrofilin hydrochloride (AC), ambroxol hydrochloride (AM), bromhexine hydrochloride (BR), and salbutamol sulfate (SS); by immersing in 3?mL of respective solutions for 1 min, three times a day at intervals of 1 hr, for 5 days. μ‐EDXRF analysis of enamel surface did not reveal significant erosion caused by the medications. However, ATR‐FTIR showed a detectable shift in the phosphate (PO <sub>4</sub> ) antisymmetric stretching mode (ν <sub>3</sub> ) at ～985 cm ?1 for AM, BR, and SS, indicating erosion. Multivariate statistical analysis showed that AC, AM, SS, and BR could be classified with 70%, 80%, 100%, and 100% efficiency from S (control), further highlighting the ability of ATR‐FTIR to identify degree of erosion. This suggests ATR‐FTIR may be used to rapidly and nondestructively investigate erosive effects of medicaments. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract XMLNS =“http://www.wiley.com/namespaces/wiley”type =“main”> <title type =“main”>抽象</ title> >药物可能在不利的某些时候减轻疾病由于酸性的性质，通过侵蚀珐琅来影响牙科健康。因此，非常希望能够快速可靠地检测这些效果。在这项研究中，我们使用微能分散X射线荧光光谱法（μ-EDXRF）评估了四种最常见的呼吸道糖浆药物的腐蚀能力，并衰减的全反射傅里叶变换红外光谱（ATR-FTIR）。从30牛牙齿获得的五十五个牙釉质片段用人工唾液，盐酸盐氯化林素盐酸盐（AC），盐酸氨苄青素（AM），盐酸溴苯并（BR）和Sal丁醇酰胺醇硫酸盐（SS）处理;通过浸入3？Ml各自的溶液中1分钟，每天三次，间隔为1小时，5天。搪瓷表面的μ-EDXRF分析没有透露由药物引起的显着侵蚀。然而，ATR-FTIR在〜985cm 1 </ sup>的磷酸盐（po <sub> 4 </ sub>）反对手拉伸模式（ν<sub> 3 </ sub>）中显示出可检测的偏移对于AM，BR和SS，表明侵蚀。多变量统计分析显示，AC，AM，SS和BR可以从S（控制）的70％，80％，100％和100％效率分类，进一步突出ATR-FTIR识别侵蚀程度的能力。这表明ATR-FTIR可用于迅速和无损地研究药物的腐蚀作用。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-24994/'>《Microscopy research and technique》</a> <b style="margin: 0 2px;">|</b><span>2018年第2期</span><b style="margin: 0 2px;">|</b><span>共9页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gomes Raimundo Nonato Silva&option=202" target="_blank" rel="nofollow">Gomes Raimundo Nonato Silva;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bhattacharjee Tanmoy T.&option=202" target="_blank" rel="nofollow">Bhattacharjee Tanmoy T.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Carvalho Luis Felipe C. S.&option=202" target="_blank" rel="nofollow">Carvalho Luis Felipe C. S.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Soares Luís Eduardo Silva&option=202" target="_blank" rel="nofollow">Soares Luís Eduardo Silva;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mao Chuanbin&option=202" target="_blank" rel="nofollow">Mao Chuanbin;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Laboratory of Dentistry and Applied Materials (LDAM)Research and Development Institute (IP&</p> <p>D) Universidade do Vale do ParaíbaS?o José dos Campos S?o Paulo Brazil;</p> <p>Laboratory of NanosensorsResearch and Development Institute (IP&</p> <p>D) Universidade do Vale do ParaíbaS?o José dos Campos S?o Paulo Brazil;</p> <p>Laboratory of Dentistry and Applied Materials (LDAM)Research and Development Institute (IP&</p> <p>D) Universidade do Vale do ParaíbaS?o José dos Campos S?o Paulo Brazil;</p> <p>Laboratory of Dentistry and Applied Materials (LDAM)Research and Development Institute (IP&</p> <p>D) Universidade do Vale do ParaíbaS?o José dos Campos S?o Paulo Brazil;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/19294.html" title="显微镜">显微镜;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=ATR‐FTIR&option=203" rel="nofollow">ATR‐FTIR;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=enamel&option=203" rel="nofollow">enamel;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=erosion&option=203" rel="nofollow">erosion;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=μ‐EDXRF&option=203" rel="nofollow">μ‐EDXRF;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=medicaments&option=203" rel="nofollow">medicaments;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=respiratory diseases&option=203" rel="nofollow">respiratory diseases;</a> </p> <div class="translation"> 机译：ATR-FIRE;珐琅质;侵蚀;μ-EDXRF;药物;呼吸系统疾病; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704023680130.html">ATR‐FTIR spectroscopy and μ‐EDXRF spectrometry monitoring of enamel erosion caused by medicaments used in the treatment of respiratory diseases</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gomes Raimundo Nonato Silva&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Gomes Raimundo Nonato Silva,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bhattacharjee Tanmoy T.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Bhattacharjee Tanmoy T.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Carvalho Luis Felipe C. 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href="/conference-cn-43145/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 2017中国光谱仪器前沿技术学术研讨会 </a> <span> <span> . 2017</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/02031550321.html">土壤呼吸作用红外光谱传感方法研究及监测系统设计</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=肖广东&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 肖广东</a> <span> . 2015</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120113401366.html">基于多光谱PPG盲源分离法的呼吸率监测方法及装置</a> <b>[P]</b> . <span> 中国专利： CN113425282A </span> <span> . 2021-09-24</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120211709926.html">用于树木病虫害监测的便携式光谱仪监测设备和监测系统</a> <b>[P]</b> . <span> 中国专利： CN211697473U </span> <span> . 2020-10-16</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130437799744.html">Medicament for the prevention and / or treatment of atherosclerosis, medicaments for inhibiting vascular smooth muscle cell proliferation, neointimal formation of blood vessels and vascular remodeling, medicament for the prevention of restenosis following percutaneous coronary intervention, and, medicines for the prophylaxis and / or treatment of hypertension or diseases caused by hypertension or diseases caused by hypertension, heart disease, angina pectoris, myocardial infarction, arrhythmia, sudden death, heart failure, cardiac hypertrophy, kidney diseases, diabetic nephropathy, glomerulonephritis, nephrosclerosis, cerebrovascular diseases, cerebral infarction, and cerebral hemorrhage</a> <b>[P]</b> . <span> 外国专利：  BRPI0406987A </span> <span> . 2006-01-10</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：用于预防和/或治疗动脉粥样硬化的药物，用于抑制血管平滑肌细胞增殖，血管新生内膜形成和血管重塑的药物，用于经皮冠状动脉介入治疗后预防再狭窄的药物，以及用于预防和/或治疗的药物高血压或由高血压引起的疾病或由高血压，心脏病，心绞痛，心肌梗塞，心律不齐，猝死，心力衰竭，心脏肥大，肾脏疾病，糖尿病肾病，肾小球肾炎，肾硬化，脑血管疾病，脑梗死和脑出血 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130425480225.html">composition, pharmaceutical composition, effervescent dosage form, multiple unit oral oral pharmaceutical composition, extended release pharmaceutical dosage form, enteric coated pharmaceutical dosage form, stable pharmaceutical dosage form for oral administration to mammalian subjects, method for treating diseases acid-related diseases by inhibiting gastric acid secretion, method for treating a bacterial infection caused or caused by helicobacter pylori, process for preparing a compound of formula 3, process for preparing a compound of formula 5, use of a compound of formula 1 for the preparation of a medicament for treating gastric acid-related diseases by inhibiting gastric acid secretion, use of a compound of formula 1 for the preparation of a medicament for treating a bacterial infection caused or caused by helicobacter pyl or use of a compound of formula 1 for the preparation of a medicament for treating gastric acid-related diseases by inhibiting gastric acid secretion</a> <b>[P]</b> . <span> 外国专利：  BRPI0617987A2 </span> <span> . 2011-08-16</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：组合物，药物组合物，泡腾剂型，多单位口服口服药物组合物，缓释药物剂型，肠溶衣药物剂型，向哺乳动物受试者口服给药的稳定药物剂型，通过抑制胃酸治疗疾病的方法酸分泌，治疗由幽门螺杆菌引起或引起的细菌感染的方法，制备式3化合物的方法，制备式5化合物的方法，式1化合物在制备用于治疗胃的药物中的用途通过抑制胃酸分泌来治疗与酸有关的疾病，将式1的化合物用于制备用于治疗由幽门螺杆菌引起或引起的细菌感染的药物，或将式1的化合物用于制备用于治疗的药物通过抑制胃酸分泌来治疗胃酸相关疾病 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130475026400.html">MEDICAMENT FOR THE TREATMENT OF RESPIRATORY DISEASES COMPRISING A MEDICAMENT AGAINST RESPIRATORY DISEASES AND A HYDROXYCYCLOHEXYLAMINE OR ONE OF ITS SALTS</a> <b>[P]</b> . <span> 外国专利：  FR2516795A1 </span> <span> . 1983-05-27</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：用于治疗呼吸道疾病的药物，包括用于治疗呼吸道疾病的药物和羟基环己胺或其盐之一 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704023680130','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> 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