Monitoring of five benzodiazepines using a novel polymeric interface prepared by layer by layer strategy

摘要

An electrochemical sensor has been successfully demonstrated for the sensitive determination of some benzodiazepines with poly dopamine-poly folic acid (P(DA-FA)) nanocomposite modified glassy carbon electrode (P(DA-FA)-GCE). Cyclic voltammetry, differential pulse voltammetry and square wave voltammetry techniques were used to investigate the electrochemical behavior of clonazepam, diazepam, alprazolam, chiordiazepoxide, oxazepam at P(DA-FA)-GCE. The cyclic voltammetric results indicate that P(DA-FA)-GCE can remarkably enhance electroactivity towards the oxidation of selected benzodiazepines in alkaline solutions. The electrochemical behavior was further exploited as a sensitive detection scheme for the benzodiazepines determination by differential-pulse voltammetry. The method was successfully applied to assay the selected drug in human plasma samples.