Production of Proteinases with Fibrinolytic and Fibrinogenolytic Activity by a Micromycete Aspergillus ochraceus

摘要

Fibrinolytic and fibrinogenolytic activity of surface and submerged cultures of a micromycete Aspergillus ochraceus L-1 was studied. Extracellular proteinases produced by A. ochraceus L-1 were found to exhibit specificity against fibrin and fibrinogen and no activity of plasminogen activators. The highest activity was observed in the cultures grown at 28 degrees C and initial pH 7.0. Fibrinolytic activity was shown to be somewhat above 25% of the total plasmin-like activity of A. ochraceus L-1 proteinases.