Synthesis and Antimalarial Activity of New Enantiopure Aminoalcoholpyrrolo[1,2-a]quinoxalines

Jonet Alexia; Guillon Jean; Mullie Catherine; Cohen Anita; Bentzinger Guillaume; Schneider Jeremy; Taudons Nicolas; Hutter Sebastien; Azas Nadine; Moreau Stephane; Savrimoutou Solene; Agnamey Patrice; Dassonville-Klimpt Alexandra; Sonnet Pascal

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Synthesis and Antimalarial Activity of New Enantiopure Aminoalcoholpyrrolo[1,2-a]quinoxalines

机译：新对映对氨基醇的合成和抗疟药活性[1,2-A]喹喔啉

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Background: We prepared a novel series of enantiopure mefloquine analogues with pyrrolo[1,2-a]quinoxaline core in order to fight Plasmodium falciparum resistant strain.

机译：背景：我们准备了一种用Pyrrolo [1,2-A]喹喔啉核心的新型对映射Meflooquine类似物核心核心，以便对抗疟原虫抗性菌株。

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来源
《Medicinal chemistry》 |2018年第3期|共11页
作者
Jonet Alexia; Guillon Jean; Mullie Catherine; Cohen Anita; Bentzinger Guillaume; Schneider Jeremy; Taudons Nicolas; Hutter Sebastien; Azas Nadine; Moreau Stephane; Savrimoutou Solene; Agnamey Patrice; Dassonville-Klimpt Alexandra; Sonnet Pascal;
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作者单位

Univ Picardie Jules Verne Lab Glycochim Antimicrobiens &

Agroressources UMR CNRS 7378 UFR Pharm;

Univ Bordeaux Lab ARNA UFR Sci Pharmaceut Bordeaux France;

Univ Picardie Jules Verne Lab Glycochim Antimicrobiens &

Agroressources UMR CNRS 7378 UFR Pharm;

Univ Picardie Jules Verne Lab Glycochim Antimicrobiens &

Agroressources UMR CNRS 7378 UFR Pharm;

Univ Picardie Jules Verne Lab Glycochim Antimicrobiens &

Agroressources UMR CNRS 7378 UFR Pharm;

Inst Rech Biomed Armees Unite Toxicol Analyt Bretigny Sur Orge France;

Univ Aix Marseille Fac Pharm Lab Parasitol &

Mycol UMR MD3 Marseille France;

Univ Aix Marseille Fac Pharm Lab Parasitol &

Mycol UMR MD3 Marseille France;

Univ Bordeaux Lab ARNA UFR Sci Pharmaceut Bordeaux France;

Univ Bordeaux Lab ARNA UFR Sci Pharmaceut Bordeaux France;

Univ Picardie Jules Verne Lab Glycochim Antimicrobiens &

Agroressources UMR CNRS 7378 UFR Pharm;

Univ Picardie Jules Verne Lab Glycochim Antimicrobiens &

Agroressources UMR CNRS 7378 UFR Pharm;

Univ Picardie Jules Verne Lab Glycochim Antimicrobiens &

Agroressources UMR CNRS 7378 UFR Pharm;

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原文格式 PDF
正文语种 eng
中图分类医用化学;
关键词
Antimalarial activity; asymmetric synthesis; aminoalcoholquinoline derivatives; aminoalcoholpyrrolo1; 2-aquinoxaline; derivatives; in vitro cytotoxicity; HepG2;

机译：抗疟疾活性;不对称合成;氨基醇喹啉衍生物;氨基醇丙醇[1;2-A]喹喔啉;衍生物;体外细胞毒性;Hepg2;

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专利

1. Synthesis and Antimalarial Activity of New Enantiopure Aminoalcoholpyrrolo[1,2-a]quinoxalines [J] . Jonet Alexia, Guillon Jean, Mullie Catherine, Medicinal chemistry . 2018,第3期

机译：新对映对氨基醇的合成和抗疟药活性[1,2-A]喹喔啉
2. Design, Synthesis and Antimalarial Activity of Some New Aminoalcohol-pyrrolo[1,2-a]quinoxaline Derivatives [J] . Guillon Jean, Moreau Stephane, Ronga Luisa, Letters in drug design & discovery . 2016,第9期

机译：一些新型氨基醇-吡咯并[1,2-a]喹喔啉衍生物的设计，合成及抗疟活性
3. New ferrocenic pyrrolo(1,2-a)quinoxaline derivatives: synthesis, and in vitro antimalarial activity. [J] . Guillon J, Moreau S, Mouray E, Bioorganic and medicinal chemistry . 2008,第20期

机译：新的二茂铁吡咯并（1,2-a）喹喔啉衍生物：合成和体外抗疟活性。
4. Synthesis and Antibacterial activity of some new quinoxaline-1,4-dioxide Derivatives [C] . Zhijun Xin, Jianping Liang, Xuehu Li, International Conference on Chemical, Material and Metallurgical Engineering . 2013

机译：一些新的喹喔啉-1,4-二氧化衍生物的合成与抗菌活性
5. New ruthenium (II)-chloroquine complexes and metal-free aminoquinolines: Synthesis, antimalarial activity and mechanism of biological action. [D] . Rajapakse, Chandima Shashikala Kumari. 2010

机译：新的钌（II）-氯喹配合物和不含金属的氨基喹啉：合成，抗疟活性和生物作用机理。
6. Synthesis and Antimicrobial Activity of Some New Substituted Quinoxalines [O] . Mohamed A. El-Atawy, Ezzat A. Hamed, Mahjoba Alhadi, 2019

机译：一些新的取代喹喔啉的合成及抑菌活性
7. Synthesis, Antimalarial Activity and Molecular Modeling of New Pyrrolo (1, 2-a)quinoxalines, Bispyrrolo(1, 2-a)quinoxalines, Bispyrido(3, 2-e)pyrrolo(1, 2-a)pyrazines and Bispyrrolo(1, 2-a)thieno(3, 2-e)pyrazines [O] . -1

机译：新吡咯（1,2-A）喹喔啉，双吡咯（1,2-A）喹喔啉，双吡啶（3,2-e）吡咯醇（1,2-A）吡嗪和吡嗪（1,2-吡咯醇（1）的合成，抗疟活动，2-a）Thieno（3,2-e）吡嗪
8. Drug Development of the Antimalarial Agent Artemisinin: Total Synthesis, AnalogSynthesis, and Structure-Activity Relationship Studies [R] . Avery, M. A. 1990

机译：抗疟药青蒿素的药物开发：全合成，类似合成和结构 - 活性关系研究

Synthesis and Antimalarial Activity of New Enantiopure Aminoalcoholpyrrolo[1,2-a]quinoxalines

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