Design, Synthesis, and Biological Evaluation of C-2 Substituted 3H-thieno[2,3-d]pyrimidin-4-one Derivatives as Novel FGFR1 Inhibitors

Guo Ping; Xie Zixin; Zhang Huan; Zhang Zaikui; Han Chao; Cheng Donghua; Lin Dan; Zhang Yuan; Wang Xuebao; Guo Xin; Ye Faqing

首页> 外文期刊>Medicinal chemistry >Design, Synthesis, and Biological Evaluation of C-2 Substituted 3H-thieno[2,3-d]pyrimidin-4-one Derivatives as Novel FGFR1 Inhibitors

【24h】

Design, Synthesis, and Biological Evaluation of C-2 Substituted 3H-thieno[2,3-d]pyrimidin-4-one Derivatives as Novel FGFR1 Inhibitors

机译：C-2取代的3H-Thieno [2,3-D]嘧啶-4-一种衍生物作为新型FGFR1抑制剂的设计，合成和生物学评价

获取原文

获取原文并翻译 | 示例

获取外文期刊封面封底 >>

开具论文收录证明 >>

文献代查 >>

团队文献服务 >>

页面导航

摘要
著录项
引文网络
相似文献
相关主题

摘要

Background: Thienopyrimidinone is a newly designed, selective fibroblast growth factor receptor 1 (FGFR1) inhibitor with an excellent anticancer effect.

机译：背景：噻吩嘧啶酮是一种新设计的选择性成纤维细胞生长因子受体1（FGFR1）抑制剂，具有优异的抗癌作用。

著录项

来源
《Medicinal chemistry》 |2017年第8期|共8页
作者
Guo Ping; Xie Zixin; Zhang Huan; Zhang Zaikui; Han Chao; Cheng Donghua; Lin Dan; Zhang Yuan; Wang Xuebao; Guo Xin; Ye Faqing;
展开▼
作者单位

Wenzhou Med Univ Sch Pharm 1210 Univ Town Wenzhou 325035 Zhejiang Peoples R China;

Wenzhou Med Univ Sch Pharm 1210 Univ Town Wenzhou 325035 Zhejiang Peoples R China;

Wenzhou Med Univ Sch Pharm 1210 Univ Town Wenzhou 325035 Zhejiang Peoples R China;

Wenzhou Med Univ Sch Pharm 1210 Univ Town Wenzhou 325035 Zhejiang Peoples R China;

Wenzhou Med Univ Sch Pharm 1210 Univ Town Wenzhou 325035 Zhejiang Peoples R China;

Wenzhou Med Univ Sch Pharm 1210 Univ Town Wenzhou 325035 Zhejiang Peoples R China;

Wenzhou Med Univ Sch Pharm 1210 Univ Town Wenzhou 325035 Zhejiang Peoples R China;

Wenzhou Med Univ Sch Pharm 1210 Univ Town Wenzhou 325035 Zhejiang Peoples R China;

Wenzhou Med Univ Sch Pharm 1210 Univ Town Wenzhou 325035 Zhejiang Peoples R China;

Wenzhou Med Univ Sch Pharm 1210 Univ Town Wenzhou 325035 Zhejiang Peoples R China;

Wenzhou Med Univ Sch Pharm 1210 Univ Town Wenzhou 325035 Zhejiang Peoples R China;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类医用化学;
关键词
FGFR1; inhibitor; thienopyrimidinone; design; synthesis; anticancer;

机译：FGFR1;抑制剂;噻吩嘧啶酮;设计;合成;抗癌;

相似文献

外文文献
中文文献
专利

1. Design, Synthesis, and Biological Evaluation of C-2 Substituted 3H-thieno[2,3-d]pyrimidin-4-one Derivatives as Novel FGFR1 Inhibitors [J] . Guo Ping, Xie Zixin, Zhang Huan, Medicinal chemistry . 2017,第8期

机译：C-2取代的3H-Thieno [2,3-D]嘧啶-4-一种衍生物作为新型FGFR1抑制剂的设计，合成和生物学评价
2. Design, synthesis, biological evaluation and docking studies of novel 2-substituted-4-morpholino-7,8-dihydro-5H-thiopyrano[4,3-d] pyrimidine derivatives as dual PI3K alpha/mTOR inhibitors [J] . Lei Fei, Sun Chengyu, Xu Shan, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2016,第Null期

机译：设计，合成，生物学评估和对接的新型2-取代-4-吗啉代7,8-二氢-5H-硫代吡喃并[4,3-d]嘧啶衍生物作为PI3Kα/ mTOR双重抑制剂
3. Design, synthesis and biological evaluation of N-phenylthieno[2,3-d]pyrimidin-4-amines as inhibitors of FGFR1 [J] . Gryshchenko A. A., Bdzhola V. G., Balanda A. O., Bioorganic and medicinal chemistry . 2015,第9期

机译：N-苯基噻吩并[2,3-d]嘧啶-4-胺作为FGFR1抑制剂的设计，合成及生物学评价
4. The design, synthesis and biological evaluation of novel substituted purines as HIV-1 Tat-TAR inhibitors [C] . Dekai Yuan, Meizi He, Ruifang Pang, 第四届国际分子模拟与信息技术应用学术会议（The 4th International Conference of Molecular Simulations and Applied Informatics Technologies）论文集 . 2008

机译：新型取代嘌呤作为HIV-1 Tat-TAR抑制剂的设计，合成和生物学评估
5. Structure-Based Drug Design in Medicinal Chemistry: I. Development of Translesion Synthesis Inhibitors II. Synthesis and Biological Evaluation of Sulfonyl Piperazine Derivatives for LpxH Inhibition [D] . Lee, Minhee 2017

机译：药物化学中基于结构的药物设计：I.跨病变合成抑制剂的开发II。磺酰哌嗪衍生物对LpxH的抑制作用及其合成及生物学评价
6. Design synthesis and biological evaluation of novel 1H-124-triazole benzothiazole and indazole-based derivatives as potent FGFR1 inhibitors viafragment-based virtual screening [O] . Jian Liu, Yu Wen, Lina Gao, 2020

机译：通过基于片段的虚拟筛选设计新型1H-124-三唑苯并噻唑和吲唑基衍生物作为强效FGFR1抑制剂的设计合成和生物学评估
7. Design, synthesis and biological evaluation of 4-bromo-N-(3,5-dimethoxyphenyl)benzamide derivatives as novel FGFR1 inhibitors for treatment of non-small cell lung cancer [O] . Zixin Xie, Donghua Cheng, Lu Luo, 2018

机译：4-溴-N-（3,5-二甲氧基苯基）苯胺衍生物作为新型FGFR1抑制剂的设计，合成和生物学评价，用于治疗非小细胞肺癌

Design, Synthesis, and Biological Evaluation of C-2 Substituted 3H-thieno[2,3-d]pyrimidin-4-one Derivatives as Novel FGFR1 Inhibitors

摘要

著录项

引文网络

相似文献

相关主题

期刊订阅