Angiotensin 1-7, but not the thrombin-cleaved osteopontin C-terminal fragment, attenuates osteopontin-mediated macrophage-induced endothelial-cell inflammation

Hamias Rachel; Rudich Assaf; Greenberg George; Szendro Gabriel; Wolak Talya

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Angiotensin 1-7, but not the thrombin-cleaved osteopontin C-terminal fragment, attenuates osteopontin-mediated macrophage-induced endothelial-cell inflammation

机译：血管紧张素1-7，但不是凝血酶切割的骨桥蛋白C-末端片段，衰减骨桥蛋白介导的巨噬细胞诱导的内皮细胞炎症

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摘要

Evaluating the pro-/anti-inflammatory activity of the C-terminal cleavage product of osteopontin in comparison to angiotensin 1-7.

机译：与血管紧张素1-7相比，评价骨桥蛋白的C末端切割产物的抗炎活性。

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来源
《Fortschritte der Physik》 |2018年第3期|共11页
作者
Hamias Rachel; Rudich Assaf; Greenberg George; Szendro Gabriel; Wolak Talya;
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作者单位

Ben Gurion Univ Negev Fac Hlth Sci Clin Biochem &

Pharmacol Beer Sheva Israel;

Soroka Univ Med Ctr Beer Sheva Israel;

Soroka Univ Med Ctr Dept Vasc Surg Beer Sheva Israel;

Soroka Univ Med Ctr Dept Vasc Surg Beer Sheva Israel;

Soroka Univ Med Ctr Hypertens Unit POB 151 IL-84101 Beer Sheva Israel;

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原文格式 PDF
正文语种 eng
中图分类物理学;
关键词
Osteopontin; OPN-N terminal; OPN-C terminal; NF kappa B; I kappa B;

机译：Osteopontin;OPN-N终端;OPN-C终端;NF Kappa B;I Kappa B;

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专利

1. Angiotensin 1-7, but not the thrombin-cleaved osteopontin C-terminal fragment, attenuates osteopontin-mediated macrophage-induced endothelial-cell inflammation [J] . Hamias Rachel, Rudich Assaf, Greenberg George, Inflammation research: Official journal of the European Histamine Research Society . 2018,第3期

机译：血管紧张素1-7，但不是凝血酶切割的骨桥蛋白C-末端片段，衰减骨桥蛋白介导的巨噬细胞诱导的内皮细胞炎症
2. The C-terminal amidated analogue of the substance P (SP) fragment SP(1-7) attenuates the expression of naloxone-precipitated withdrawal in morphine dependent rats. [J] . Zhou Q, Carlsson A, Botros Peptides: An International Journal . 2009,第12期

机译：P（SP）片段SP（1-7）的C端酰胺化类似物减弱吗啡依赖性大鼠中纳洛酮沉淀的戒断反应的表达。
3. N-terminal rather than full-length osteopontin or its C-terminal fragment is associated with carotid-plaque inflammation in hypertensive patients [J] . WolakT., Sion-VardiN., NovackV., American Journal of Hypertension . 2013,第3期

机译：高血压患者的N端而非全长骨桥蛋白或其C端片段与颈动脉斑块炎症有关
4. Angiotensin (1-7) attenuates the chronotropic response to Angiotensin II via stimulation of PTEN in spontaneously hypertensive rat brain. [D] . Modgil, Amit. 2013

机译：血管紧张素（1-7）通过刺激自发性高血压大鼠大脑中的PTEN减弱了对血管紧张素II的变时反应。
5. Thrombin-cleaved Fragments of Osteopontin Are Overexpressed in Malignant Glial Tumors and Provide a Molecular Niche with Survival Advantage [O] . Yasuto Yamaguchi, Zhifei Shao, Shadi Sharif, 2013

机译：骨桥蛋白的凝血酶裂解片段在恶性胶质瘤中过表达并提供具有生存优势的分子生态位
6. N-Terminal Rather Than Full-Length Osteopontin or Its C-Terminal Fragment Is Associated With Carotid-Plaque Inflammation in Hypertensive Patients [O] . T. Wolak, N. Sion-Vardi, V. Novack, 2013

机译：n末端而不是全长骨桥蛋白或其C末端片段与高血压患者的颈动脉斑炎症有关

Angiotensin 1-7, but not the thrombin-cleaved osteopontin C-terminal fragment, attenuates osteopontin-mediated macrophage-induced endothelial-cell inflammation

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