Electrospun Heparin‐Loaded Core–Shell Nanofiber Sutures for Achilles Tendon Regeneration In Vivo

Ye Ya‐Jing; Zhou Ya‐Qing; Jing Zhuo‐Yuan; Liu Yang‐Yang; Yin Da‐Chuan

摘要

Abstract >Achilles tendon reconstruction surgery is the primary clinical method for repairing acute Achilles tendon ruptures. However, the efficacy of the postoperative healing process and the recovery of physiological function are inadequate. This study examines the healing mechanism of ruptured rat Achilles tendons seamed with heparin‐loaded core–shell fiber sutures fabricated via near‐field electrospinning. High‐heparin‐concentration sutures (PPH3.0) perform better than the low‐heparin‐concentration sutures and commercial sutures (CSs). The PPH3.0 suture recruits fewer inflammatory cells and shows good histocompatibility in peritoneal implantation experiments. Staining of the Achilles tendon rupture repair zone demonstrates that a high heparin concentration in sutures reduces immune‐inflammatory responses. Immunohistochemical analysis reveals that the transforming growth factor‐β staining scores of the PPH3.0 sutures are not significantly different from those of the corresponding control group but are significantly different from those of the CSs and non‐heparin‐loaded‐suture groups. According to vascular endothelial growth factor (VEGF) analysis, the concentration of VEGF in the group treated with the PPH3.0 suture increases by 37.5% compared with that in its control group. No significant difference in tension strength is observed between the PPH3.0 group and healthy Achilles tendons. These findings illustrate that this novel method effectively treats Achilles tendon rupture and promotes healing and regeneration. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>摘要</标题> > Achilles肌腱重建手术是修复急性阿基里斯肌腱破裂的主要临床方法。然而，术后愈合过程和生理功能恢复的疗效不足。本研究检测破裂大鼠脑肌腱与通过近场静电纺丝制造的肝素负载的核 - 壳纤维缝合物接缝的愈合机制。高肝素浓度缝合线（PPH3.0）比低肝素浓度缝合线和商业缝合线（CSS）更好。 PPH3.0缝合线促进较少的炎性细胞，在腹膜植入实验中显示出良好的组织相容性。 Achilles肌腱破裂修复区的染色证明缝合线中的高肝素浓度降低了免疫炎症反应。免疫组织化学分析表明，PPH3.0缝合线的转化生长因子-β染色得分与相应对照组的转化性没有显着不同，但与CSS和非肝素负载缝合线的显着不同。根据血管内皮生长因子（VEGF）分析，用PPH3.0缝合线处理的基团中VEGF的浓度增加37.5％，与其对照组相比。 PPH3.0组和健康的Achilles腱之间没有观察到张力强度的显着差异。这些发现表明，这种新方法有效地治疗阿基尔斯肌腱破裂并促进愈合和再生。</ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" > 著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-24307/'>《Macromolecular bioscience 》</a> <b style="margin: 0 2px;">|</b><span>2018年第7期</span><b style="margin: 0 2px;">|</b> <span>共12页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ye Ya‐Jing&option=202" target="_blank" rel="nofollow">Ye Ya‐Jing;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhou Ya‐Qing&option=202" target="_blank" rel="nofollow">Zhou Ya‐Qing;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jing Zhuo‐Yuan&option=202" target="_blank" rel="nofollow">Jing Zhuo‐Yuan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liu Yang‐Yang&option=202" target="_blank" rel="nofollow">Liu Yang‐Yang;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yin Da‐Chuan&option=202" target="_blank" rel="nofollow">Yin Da‐Chuan;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Key Laboratory for Space Bioscience and BiotechnologyNorthwestern Polytechnical UniversityXi'an 710072 China;</p> <p>Key Laboratory for Space Bioscience and BiotechnologyNorthwestern Polytechnical UniversityXi'an 710072 China;</p> <p>Key Laboratory for Space Bioscience and BiotechnologyNorthwestern Polytechnical UniversityXi'an 710072 China;</p> <p>Key Laboratory for Space Bioscience and BiotechnologyNorthwestern Polytechnical UniversityXi'an 710072 China;</p> <p>Key Laboratory for Space Bioscience and BiotechnologyNorthwestern Polytechnical UniversityXi'an 710072 China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li> <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span> <a href="https://www.zhangqiaokeyan.com/clc/1185.html" title="高分子化学（高聚物）">高分子化学（高聚物） ;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Achilles tendon rupture&option=203" rel="nofollow">Achilles tendon rupture;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=core–shell fiber&option=203" rel="nofollow">core–shell fiber;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=electrospinning&option=203" rel="nofollow">electrospinning;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=heparin‐loaded sutures&option=203" rel="nofollow">heparin‐loaded sutures;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=tendon regeneration&option=203" rel="nofollow">tendon regeneration;</a> </p> <div class="translation"> 机译：Achilles肌腱破裂;核 - 壳纤维;静电纺丝;肝素装载缝合线;肌腱再生; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704023543492.html">Electrospun Heparin‐Loaded Core–Shell Nanofiber Sutures for Achilles Tendon 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href="/academic-degree-domestic_mphd_thesis/020313266371.html">从缝缝补补的针到开天辟地的斧——电影特技的演进及其对电影本体论的革命</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=邓煜&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 邓煜</a> <span> . 2008</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120102292906.html">双线锁缝缝纫机向单线锁缝缝纫机的变换方法及锁缝缝纫机</a> <b>[P]</b> . <span> 中国专利： CN103526464A </span> <span> . 2014-01-22</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120100213796.html">一种边缝缝纫机的收料板机构及边缝缝纫机</a> <b>[P]</b> . <span> 中国专利： CN109208191A </span> <span> . 2019-01-15</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130421827853.html">METHOD OF SURGICAL TREATMENT OF FRESH RUPTURES OF ACHILLES TENDON WITH STEP-BY-STEP MONITORING OF TENDON SUTURE STABILITY IN CONDITIONS OF MOBILISATION IN POSTOPERATION AND REHABILITATION PERIODS</a> <b>[P]</b> . <span> 外国专利：  RU2436536C1 </span> <span> . 2011-12-20</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：在手术后和康复期间动员的情况下，通过逐步监测肌腱缝合稳定性的方法，对骨肌腱的新鲜破裂进行外科治疗 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130424217751.html">Harpoon to the surgical repair of a tom tendon, for example, the achilles tendon, and method of fixing the hook on a suture thread</a> <b>[P]</b> . <span> 外国专利：  FR2927526B1 </span> <span> . 2011-02-11</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：鱼叉用于外科手术修复例如腱，脚跟腱以及将钩子固定在缝合线上的方法 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130426680707.html">Suture needle for surgical repair of rupture tendon i.e. Achilles tendon, of patient, has pointed end located in continuity of generatrix of cylindrical central portion presenting largest radius of curvature</a> <b>[P]</b> . <span> 外国专利：  FR2938421A1 </span> <span> . 2010-05-21</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：用于外科手术的断裂肌腱即患者的跟腱的缝合针的尖端位于圆柱形中央部分的母线的连续性处，呈现最大的曲率半径 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704023543492','4',7,2,1,'',this,24)" 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