Treatment of cervical cancer precursors: influence of age, completeness of excision and cone depth on therapeutic failure, and on adverse obstetric outcomes.

摘要

Sir,The use of less aggressive electrosurgical loop excision of high-grade cervical intraepithelial neoplasia (HGCIN), defined as CIN2 or CIN3, has been shown to be associated with an increased risk of recurrence of the disease, and therefore probably also of cancer. However, large excision of HGCIN is also associated with an increased risk of subsequent preterm delivery and low birthweight. Therefore, there is a need for further research to find the optimum depth and width for such loop excisions in these women. An increase in the risk of preterm delivery with deeper excisions has been described throughout the literature, but meta-analytical pooling is compromised by the lack of uniformly reported excisional measurements.