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Lactobacillus caseiimproves depression-like behavior in chronic unpredictable mild stress-induced rats by the BDNF-TrkB signal pathway and the intestinal microbiota

机译:Lactobacillus caseIImproves在慢性不可预测的轻度胁迫诱导的大鼠中的抑郁样行为通过BDNF-TRKB信号途径和肠道微生物

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摘要

Lactobacillus casei(L. casei), a kind of probiotics, is known as a "healthy triple benefit bacterium" along withLactobacillus acidophilusandBifidobacterium.L. caseiis associated with the alteration of the intestinal flora population, and the gut microbiota-brain axis has been demonstrated to play an important role in many central nervous system diseases. The aim of this study was to evaluate the effectiveness ofL. caseiintervention in ameliorating mental disorders and potential mechanisms using a rat model with depression-like behaviour induced by chronic unpredictable mild stress (CUMS).L. caseiintervention improved the CUMS-induced depression-like behaviors of rats, including a reduced body growth rate, decreased sucrose preference, increased immobility time, and lowered moving distance and velocity. In addition,L. caseiintervention amended the gut microbiota structure changes induced by CUMS in rats. Furthermore,L. caseiintervention reversed the CUMS-induced protein expression changes of monoamines dopamine, noradrenaline and 5-hydroxytryptamine, brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase receptor B (TrkB), andN-methyl-d-aspartic acid receptor 1, as well as CUMS-induced activations of ERK1/2 and p38 MAPK signal pathways. These findings suggested thatL. caseicould significantly protect against depression in rats, which was possibly associated with the alterations in the gut microbiota composition and mediation of BDNF-TrkB signaling.
机译:乳酸杆菌(L.酪虫),一种益生菌,被称为“健康三重益菌细菌”,其伴随着嗜酸杆菌酸碱杆菌。与肠道菌群群体改变相关的肠肠杆菌,并且肠道微生物群轴轴已经证明在许多中枢神经系统疾病中起重要作用。本研究的目的是评估效果。用大鼠模型改善精神障碍和潜在机制,慢性不可预测的温和胁迫(CUMS)。酪蛋白intervention改善了大鼠的抑制性抑郁症的行为,包括减少的体长速率,降低蔗糖偏好,增加的不动时间,降低移动距离和速度。另外,l。酪蛋白是修改了CUMS在大鼠中诱导的肠道微生物群结构变化。此外,L。酪蛋白intervention逆转了单胺类多巴胺,去甲肾上腺素和5-羟基特胺,脑衍生的神经营养因子(BDNF)及其受体酪氨酸激酶受体B(TRKB),AndN-甲基-D-天冬氨酸受体1的Cums-诱导的蛋白表达变化。以及CUMS诱导的ERK1 / 2和P38 MAPK信号途径的激活。这些调查结果表明了。表壳可显着保护大鼠的抑郁症,这可能与肠道微生物群组成和BDNF-Trkb信号传导的调节中的改变相关。

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    《Food & Function》 |2020年第7期|共10页
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  • 正文语种 eng
  • 中图分类 食品工业;
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