Determination of Personal Care Products in Fish Tissue Based on Matrix Solid-Phase Dispersion Combined with Programmable Split/Splitless Injector Gas Chromatography-Mass Spectrometry

摘要

An analytical method was developed and validated for the simultaneous determination in fish muscle of two kinds of emerging pollutants: polycyclic aromatic musks (galaxolide and tonalide) and UV filters [oxybenzone, 3-(4-methylbenzylidene) camphor, padimate-O, 2-ethylhexyl 4-methoxycinnamate, octocrylene], which are very common ingredients of personal care products, by programmable split/splitless injector gas chromatography-mass spectrometry (PSSI-GC-MS) using a matrix solid-phase dispersion (MSPD) for extraction and clean-up procedure in a single step. The method was evaluated for precision (relative standard deviation & 19%), linearity (r (2) & 0.9829); accuracy, reported as % of recovery; limit of quantification (0.013 to 0.040 mu g g(-1), referred to dry mass); and limit of detection (0.004 to 0.012 mu g g(-1), referred to dry mass) for each of the analytes. The average recoveries in muscle samples spiked at two levels: 0.1 mu g g(-1) and 1.0 mu g g(-1) ranged between 77-111% and 55-108%, respectively. The method was applied for the determination of the mentioned pollutants in an exposure in vivo study with rainbow trout, and the results showed a larger absorption of musks (tonalide 43.0 mu g g(-1)) than UV filters (padimate-O, 1.0 mu g g(-1)). The proposed procedure has demonstrated to be able for simultaneous monitoring of these two different kinds of common emerging pollutants coming from personal care products, which would make it a useful tool for quality control and safety studies.