Determination of Eight Benzoylurea Insecticides in High-Fat Foodstuff Samples by Gel Permeation Chromatography Followed by High-Performance Liquid Chromatography-Tandem Mass Spectrometry

摘要

It is rather challengeable to extract hydrophobic pesticides from the complicated matrices which contain relatively high fatty compounds and ensure high recoveries of target analytes and low levels of coextracted. This paper introduces a simple, quick, and sensitive method for the determination of eight benzoylurea insecticides (BUs) in nuts via gel permeation chromatography (GPC) cleanup coupled with high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). By this method, no significant matrix effects were observed. Calibration curves for eight BUs showed good linearity in the range of 10.0 to 500.0 mu g kg(-1) with correlation coefficients in excess of 0.9990. Meanwhile, recoveries of them were between 82.8 and 113.2% with relative standard derivations lower than 11% at three spiked concentration levels in real samples in walnut, badam, and sweet almond. Limits of quantification were ranged from 1.8 to 9.7 mu g kg(-1). It proved that the proposed analytical method can be promising technique for the simultaneous determination of multihydrophobic pesticides in nut and other foodstuff samples with high fat content.