Gingerly effervescent tablets: investigating the effect of cytotoxicity on gingival fibroblasts! and antimicrobial properties under laboratory conditions

摘要

Ginger is a medicinal planl n ith antioxidant, anti-bacterial, anti-inflammatory and anti-fungal properties. The shape of effervescent tablet is a new form of this product for use as a mouthwash. This study investigated the cytotoxicity and antimicrobial properties of gingerly effervescent tablets under laboratory conditions. In this study. MTT assay was done to evaluate in-vitro gingival fibroblast cytotoxicity during 24. 48 and 72 hours. In addition, the effect of antimicrobial properties on common bacterial and oral fungi was investigated.P-value was considered significantly less than 0.05. There was no significant difference between the mean of live cells in groups with 24, 48 and 72 duration (P-value = 0.071 ). There was no significant difference between ginger group and control group (PO.05). Minimum inhibitory concentration (MIC) of effervescent tablet was different, ranging from 10 rug/ml for Candidas family to 20 mg/ml for Staphylococcus and 40 mg/ml for negative grams. According to the results, it can be concluded that gingerly effervescent tablets have no toxic effect after 72 hours of exposureto gingival fibroblasts. Its suitable antimicrobial properties for fungi makes it useful for the control of infection and as an ideal mouthwash.