Application of lipid nanoparticles to ocular drug delivery

摘要

Eye drops have been globally accepted as a formulation for anterior segment applications, although they are also associated with some limitations in terms of desired pharmacological and pharmacokinetic profile, dosing frequency, systemic untoward effects, patient non-compliance, low drug bioavail-ability due to transient contact time, rapid washout by tearing, and lachrymal drainage [1]. In addition, conventional ocular formulations are generally unable to overcome the anatomical/physiological barriers between eye surface and the inner eye structures. Therefore, effective ocular drug delivery is a challenging proposition for the pharmaceutical scientist, and nanotechnoloqy approaches can improve the therapeutic effi-ciency, compliance, and safety of ocular drugs