Dissolving microneedles for intradermal vaccination: manufacture, formulation, and stakeholder considerations

摘要

1. Introduction, Dissolving microneedle (DMN) arrays are minimally invasive devises that consist of a series of microscopic needles on a base support. Upon insertion into the skin, the needles dissolve depositing their payload (Figure 1(A-C) [1]. DMN have received substantial interest for intradermal vaccination due to their ease of use and possibility for self-administration. DMN research is close to commercialization. However, moving forward, there remain a number of concerns which warrant investigation. Herein, such considerations are discussed with a specific focus on the key challenges for DMN industrialization being highlighted.