Clinical experience with drug delivery systems as tools to decrease the toxicity of anticancer chemotherapeutic agents

Maranhao Raul C.; Vital Carolina G.; Tavoni Thauany M.; Graziani Silvia R.

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Clinical experience with drug delivery systems as tools to decrease the toxicity of anticancer chemotherapeutic agents

机译：药物递送系统作为减少抗癌化学治疗剂毒性的临床经验

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Introduction: The toxicity of chemotherapeutic agents, resulting from their low pharmacological index, introduces considerable discomfort and risk to cancer patients. Among several strategies to reduce the toxicity of chemotherapeutic agents, targeted drug delivery is the most promising one.

机译：引言：由低药理学指数引起的化学治疗剂的毒性引起了相当大的不适和癌症患者的风险。在降低化学治疗剂的毒性的几种策略中，靶向药物递送是最有前途的。

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《Expert opinion on drug delivery》 |2017年第12期|共10页
作者
Maranhao Raul C.; Vital Carolina G.; Tavoni Thauany M.; Graziani Silvia R.;
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作者单位

Univ Sao Paulo Med Sch Hosp Heart Inst Sao Paulo Brazil;

Univ Sao Paulo Med Sch Hosp Heart Inst Sao Paulo Brazil;

Univ Sao Paulo Med Sch Hosp Heart Inst Sao Paulo Brazil;

Univ Sao Paulo Med Sch Hosp Heart Inst Sao Paulo Brazil;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Cancer treatment; chemotherapy toxicity; drug targeting; LDL receptors and cancer; lipid core particles; liposomes; nanoemulsions; polymeric nanoparticles;

机译：癌症治疗;化疗毒性;药物靶向;LDL受体和癌症;脂质核心颗粒;脂质体;纳米乳液;聚合物纳米颗粒;

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专利

1. Clinical experience with drug delivery systems as tools to decrease the toxicity of anticancer chemotherapeutic agents [J] . Maranhao Raul C., Vital Carolina G., Tavoni Thauany M., Expert opinion on drug delivery . 2017,第7a12期

机译：药物递送系统作为减少抗癌化学治疗剂毒性的临床经验
2. Decreasing systemic toxicity via transdermal delivery of anticancer drugs. [J] . Fang JY, Liu PF, Huang CM Current drug metabolism . 2008,第7期

机译：通过透皮递送抗癌药降低全身毒性。
3. Decreasing Systemic Toxicity Via Transdermal Delivery of Anticancer Drugs [J] . Jia-You Fang Pei-Feng Liu Chun-Ming Huang Current Drug Metabolism . 2008,第7期

机译：通过透皮递送抗癌药降低全身毒性
4. Experiences with experimental clinical evaluation of a computerized drug delivery system for regulation of mean arterial blood pressure [C] . Kwok, K.E., Shah, . 1999

机译：调节平均动脉血压的计算机化药物输送系统的临床实验评估经验
5. Design, synthesis and biological evaluation of novel taxane-based anticancer agents and their applications to tumor-targeting drug delivery systems [D] . Zhao, Xianrui 2009

机译：基于紫杉烷类新型抗癌药的设计，合成和生物学评估及其在靶向肿瘤的药物递送系统中的应用
6. Tumor vascular-targeted co-delivery of anti-angiogenesis and chemotherapeutic agents by mesoporous silica nanoparticle-based drug delivery system for synergetic therapy of tumor [O] . Xiaoyu Li, Meiying Wu, Limin Pan, 1988

机译：介孔二氧化硅纳米粒子为基础的药物协同治疗肿瘤血管靶向共同递送抗血管生成和化学治疗剂
7. Oral delivery of chemotherapeutic agents: background and potential of drug delivery systems for colon delivery [O] . C. A. Schoener 2013

机译：口服递送化学治疗剂：用于结肠递送的药物递送系统的背景和潜力
8. Study of Chronic Toxicity of Various Classes of Cancer Chemotherapeutic Agents. Serial Studies of Serum Enzymes in Drug-Induced Hepatotoxicity in Dogs;NSC-79037 (chloroethylcyclohexyl-nitrosourcea) and NSC-406021 (ar abinosyl-6-mercaptopurine). [R] . henry,mary c. marlow,marilyn 1972

机译：各类癌症化疗药物慢性毒性研究。药物诱导的犬肝毒性中血清酶的系列研究; NsC-79037（氯乙基环己基 - 亚硝基鎓）和NsC-406021（ar abososyl-6-mercaptopurine）。

Clinical experience with drug delivery systems as tools to decrease the toxicity of anticancer chemotherapeutic agents

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