首页> 外文期刊>European Journal of Obstetrics, Gynecology and Reproductive Biology: An International Journal >Elevated basal progesterone levels are associated with increased preovulatory progesterone rise but not with higher pregnancy rates in ICSI cycles with GnRH antagonists
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Elevated basal progesterone levels are associated with increased preovulatory progesterone rise but not with higher pregnancy rates in ICSI cycles with GnRH antagonists

机译:升高的基础孕酮水平与增强的孕酮升高,但没有妊娠率较高的ICSI循环与GNRH拮抗剂的妊娠率

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Abstract Objective To ascertain the association between basal progesterone (P) levels and the occurrence of preovulatory progesterone rise (PPR) and clinical pregnancy rates (CPRs) in ICSI cycles with GnRH antagonists. Study design Serum P levels of 464 patients were measured on day 2 and day of hCG of cycles. Cycles with basal P levels 1.6 ng/mL were cancelled. All embryos were cryopreserved in cycles with P levels ≥ 2 ng/mL on the day of hCG. The primary outcome measures were the incidence of PPR (P 1.5 ng/mL) and CPR with regard to basal P. Results Basal P levels were significantly higher in cycles with PPR than in those without PPR (0.63 ± 0.31 vs. 0.48 ± 0.28 ng/mL). Area under the curve for basal P according to ROC analysis to discriminate between elevated and normal P levels on the day of hCG was 0.65 (0.58–0.71 95% CI, p 0.01). The cut-off value for basal P levels that best discriminates between cycles with and without PPR was 0.65 ng/mL. Cycles with basal P levels above 0.65 ng/mL had a significantly higher incidence of PPR (30.9% vs. 13.5%) but similar clinical and cumulative pregnancy rates (38.8% vs. 31.1% and 41.7% vs. 32.6%, respectively) in comparison to cycles with basal P levels below 0.65 ng/mL. In multivariate regression analysis, basal P levels, LH level on the first day of antagonist administration, and estradiol levels on the day of hCG trigger were the variables that predicted PPR. Conclusion Basal P levels were associated with increased incidence of PPR but not with CPR.
机译:摘要目的确定基础孕酮(P)水平与鉴定性循环中的基础孕酮(P)水平与临床妊娠(PPR)和临床妊娠率(CPRS)的发生。研究设计血清P含量为464名患者在HCG的循环的第2天和的患者中测量。循环与基础P级别& 1.6 Ng / ml被取消。在HCG的当天,在P含量≥2ng/ ml的循环中,在循环中冷冻保存所有胚胎。主要结果措施是PPR(P&GT; 1.5 Ng / ml)的发病率,CPR关于基础P.结果基础P水平在PPR的循环中显着高于没有PPR的循环(0.63±0.31与0.48±0.48±0.48±0.48±0.48± 0.28 ng / ml)。根据ROC分析的基础P曲线下的区域,以区分HCG当天升高和正常P水平为0.65(0.58-0.71 95%CI,P <0.01)。基底P级别的截止值最佳判别在循环与不具有PPR之间的循环中为0.65ng / ml。基础P含量高于0.65ng / mL的循环具有显着更高的PPR发病率(30.9%与13.5%),但临床和累积妊娠率类似(38.8%,分别为31.1%和41.7%)与基底P级别低于0.65 ng / ml的循环比较。在多元回归分析中,拮抗剂给药第一天的基础P水平,LH水平,以及HCG触发当天的雌二醇水平是预测PPR的变量。结论基础P水平与PPR的发病率增加有关,但不具有CPR。

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