Eukaryotic and prokaryotic promoter databases as valuable tools in exploring the regulation of gene transcription: a comprehensive overview

摘要

Abstract The complete exploration of the regulation of gene expression remains one of the top-priority goals for researchers. As the regulation is mainly controlled at the level of transcription by promoters, study on promoters and findings are of great importance. This review summarizes forty selected databases that centralize experimental and theoretical knowledge regarding the organization of promoters, interacting transcription factors (TFs) and microRNAs (miRNAs) in many eukaryotic and prokaryotic species. The presented databases offer researchers valuable support in elucidating the regulation of gene transcription. Highlights ? The databases can assist researchers exploring the regulation of gene expression. ? They describe promoters and their interaction with TFs and microRNAs. ? They contain information on the influence of external factors on transcription. ? Many eukaryotic and prokaryotic species, including model organisms, are incorporated. ? The data are experimental and in silico predicted.