Receptor-independent spread of a neurotropic murine coronavirus MHV-JHMV in mixed neural culture.

摘要

1. INTRODUCTION Highly neurovirulent mouse hepatitis virus (MHV) JHMV strain multiplies in a variety of brain cells, although the expression of its receptor, carcinoembryonic antigen cell adhesion molecule 1 (CEACAM 1, MHVR), is expressed only in microglia/macrophages in the brain.The present study was undertaken to clarify the mechanism of extensive JHMV infection of the brain by using neural cells isolated from mice.