Can we mimic skeletal muscles for novel drug discovery?

Broer Torie; Khodabukus Alastair; Bursac Nenad

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Can we mimic skeletal muscles for novel drug discovery?

机译：我们可以模仿新药发现的骨骼肌吗？

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来源
《Expert opinion on drug discovery》 |2020年第6期|共3页
作者
Broer Torie; Khodabukus Alastair; Bursac Nenad;
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作者单位

Duke Univ Dept Biomed Engn Durham NC 27706 USA;

Duke Univ Dept Biomed Engn Durham NC 27706 USA;

Duke Univ Dept Biomed Engn Durham NC 27706 USA;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Skeletal muscle; toxicity; drug development; tissue engineering; dystrophy;

机译：骨骼肌;毒性;药物发展;组织工程;营养不良;

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专利

1. Can we mimic skeletal muscles for novel drug discovery? [J] . Broer Torie, Khodabukus Alastair, Bursac Nenad Expert opinion on drug discovery . 2020,第1a6期

机译：我们可以模仿新药发现的骨骼肌吗？
2. DeepNEU: artificially induced stem cell (aiPSC) and differentiated skeletal muscle cell (aiSkMC) simulations of infantile onset POMPE disease (IOPD) for potential biomarker identification and drug discovery [J] . Sally Esmail, Wayne Robert Danter Frontiers in Cell and Developmental Biology . 2019,第1期

机译：DeepNEU：人工诱发的干细胞（aiPSC）和分化的骨骼肌细胞（aiSkMC）模拟婴儿发作性POMPE疾病（IOPD）的潜在生物标记物识别和药物开发
3. DeepNEU: artificially induced stem cell (aiPSC) and differentiated skeletal muscle cell (aiSkMC) simulations of infantile onset POMPE disease (IOPD) for potential biomarker identification and drug discovery [J] . Sally Esmail, Wayne Robert Danter Frontiers in Cell and Developmental Biology . 2019,第1期

机译：DeepNEU：人工诱发的干细胞（aiPSC）和分化的骨骼肌细胞（aiSkMC）模拟婴儿发作性POMPE疾病（IOPD）的潜在生物标记物识别和药物开发
4. Decellularized Skeletal Muscle Extracellular Matrix as an in vitro Model for Intramuscular Drug Development [C] . Jean J Wang, Gerry R. Boss, Karen L. Christman Society for Biomaterials annual meeting and exposition . 2013

机译：脱细胞的骨骼肌细胞外基质作为肌内药物开发的体外模型
5. Engineering new tools for targeted drug discovery: Design and development of soluble, screenable mimics for challenging proteins [D] . Audu, Christopher O. 2013

机译：设计用于靶向药物发现的新工具：设计和开发具有挑战性的蛋白质的可溶性可筛选模拟物
6. Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs [O] . Lauran Madden, Mark Juhas, William E Kraus, 2015

机译：生物工程化的人肌束模拟骨骼肌对药物的临床反应
7. Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs. [O] . Madden L, Juhas M, Kraus WE, 2015

机译：生物工程人类myobundles模仿骨骼肌对药物的临床反应。

Can we mimic skeletal muscles for novel drug discovery?

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