背景：骨骼肌损伤的再生与修复能力受多种因素的影响和调节，已知骨骼肌的肌球蛋白重链、骨骼肌胶原成分与骨骼肌损伤修复有关。 目的：总结骨骼肌生长因子、肌球蛋白及胶原在骨骼肌损伤后再生与修复过程中的变化及作用。 方法：检索PubMed和万方数据库2002至2015年有关骨骼肌生长因子、肌球蛋白和骨骼肌胶原与骨骼肌损伤修复的相关中文和英文文献。通过文献资料综合运动与骨骼肌损伤修复有关的影响因素，并对骨骼肌损伤修复过程中参与骨骼肌损伤后再生的生长因子进行归纳，分析骨骼肌生长因子、肌球蛋白重链及胶原在骨骼肌损伤修复中的作用。 结果与结论：胰岛素样生长因子、成纤维细胞生长因子和肝细胞生长因子等骨骼肌生长因子对骨骼肌损伤后炎症反应起多效性调节；肌球蛋白重链可作为再生骨骼肌的特异性标记物；Ⅰ、Ⅲ型胶原及其纤连蛋白mRNA表达作为再生肌纤维的支持骨架，对骨骼肌损伤后的再生与修复质量有着十分重要的意义。%BACKGROUND:Regeneration and repair of injured skeletal muscle are influenced by a variety of factors. Skeletal muscle myosin heavy chain and skeletal muscle col agen content are known to be involved in the repair of injured skeletal muscle. OBJECTIVE:To summarize the changes and roles of skeletal muscle growth factors, myosin, and col agen in the repair of injured skeletal muscle. METHODS:A computer-based online search was conducted in PubMed and Wanfang databases from 2002 to 2015 to screen the relevant literatures. Roles of skeletal muscle growth factors, myosin, and col agen in the repair of injured skeletal muscle was summarized by col ecting the data regarding the factors influencing exercise and the repair of injured skeletal muscle, and growth factors involved in the regeneration and repair of injured skeletal muscle. RESULTS AND CONCLUSION:Insulin-like growth factor, fibroblast growth factor and hepatocyte growth factor regulate inflammation after skeletal muscle injury extensively. Myosin heavy chain is considered as a specific marker for skeletal muscle regeneration. Types I and III col agen and fibronectin functioning as a skeleton for skeletal muscle fiber play critical roles in the regeneration and repair of injured skeletal muscle.
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