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首页> 外文期刊>Experimental and therapeutic medicine >Restoration of orbicularis oculi muscle function in rabbits with peripheral facial paralysis via an implantable artificial facial nerve system
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Restoration of orbicularis oculi muscle function in rabbits with peripheral facial paralysis via an implantable artificial facial nerve system

机译:通过植入人工面神经系统恢复兔子兔的腹膜肌肉作用,具有外周面部瘫痪

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The purpose of the present study was to restore orbicularis oculi muscle function using the implantable artificial facial nerve system (IAFNS). The in vivo part of the IAFNS was implanted into 12 rabbits that were facially paralyzed on the right side of the face to restore the function of the orbicularis oculi muscle, which was indicated by closure of the paralyzed eye when the contralateral side was closed. Wireless communication links were established between the in vivo part (the processing chip and microelectrode) and the external part (System Controller program) of the system, which were used to set the working parameters and indicate the working state of the processing chip and microelectrode implanted in the body. A disturbance field strength test of the IAFNS processing chip was performed in a magnetic field dark room to test its electromagnetic radiation safety. Test distances investigated were 0, 1, 3 and 10 m, and levels of radiation intensity were evaluated in the horizontal and vertical planes. Anti-interference experiments were performed to test the stability of the processing chip under the interference of electromagnetic radiation. The fully implanted IAFNS was run for 5 h per day for 30 consecutive days to evaluate the accuracy and precision as well as the long-term stability and effectiveness of wireless communication. The stimulus intensity (range, 0-8 mA) was set every 3 days to confirm the minimum stimulation intensity which could indicate the movement of the paralyzed side was set. Effective stimulation rate was also tested by comparing the number of eye-close movements on both sides. The results of the present study indicated that the IAFNS could rebuild the reflex arc, inducing the experimental rabbits to close the eye of the paralyzed side. The System Controller program was able to reflect the in vivo part of the artificial facial nerve system in real-time and adjust the working pattern, stimulation intensity and frequency, range of wave and stimulation time. No significant differences in the stimulus intensities were observed during 30 days. The artificial facial nerve system chip operation stable in the anti-interference test, and the radiation field strength of the system was in a safe range according to the national standard. The IAFNS functioned without any interference and was able to restore functionality to facially paralyzed rabbits over the course of 30 days.
机译:本研究的目的是使用可植入的人造面神经系统(IAFN)恢复orbicularis oculi肌肉功能。 IAFN的体内部分被植入到12只兔子上,该兔子面临垂直于面部右侧,以恢复orbicularis oculi肌肉的功能,当对侧封闭时,通过闭合瘫痪的眼睛表示。在系统的体内(处理芯片和微电极)和系统的外部部分(系统控制器程序)之间建立了无线通信链路,用于设置工作参数并指示处理芯片的工作状态和植入的微电极在身体里。在磁场暗室中进行IAFN处理芯片的扰动场强度测试,以测试其电磁辐射安全。研究的测试距离为0,1,3和10μm,在水平和垂直平面中评估辐射强度水平。进行抗干扰实验以在电磁辐射干扰下测试处理芯片的稳定性。连续30天每天运行完全植入的IAFN,以评估准确性和精度以及无线通信的长期稳定性和有效性。每3天设定刺激强度(范围,0-8 mA)以确认可能表示瘫痪侧的运动的最小刺激强度。通过比较两侧的眼睛闭合运动数,还测试了有效的刺激速率。本研究结果表明,IAFN可以重建反射弧,诱导实验兔以闭上瘫痪侧的眼睛。系统控制器程序能够实时地反映人造面神经系统的体内部分,并调整波和刺激时间的工作模式,刺激强度和频率,范围。在30天内未观察到刺激强度的显着差异。人工面神经系统芯片操作在抗干扰试验中稳定,并且根据国家标准,系统的辐射场强度处于安全范围内。 IAFN在没有任何干扰的情况下运行,并且能够在30天内恢复到面部瘫痪的兔子的功能。

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