Costimulatory T-cell engagement by PRS-343, a CD137 (4-1BB)/HER2 bispecific, leads to tumor growth inhibition and TIL expansion in a humanized mouse model

Hinner M. J.; Aiba R. S. Bel; Schlosser C.; Jaquin T.; Allersdorfer A.; Berger S.; Wiedenmann A.; Matschiner G.; Schueler J.; Moebius U.; Rothe C.; Olwill S. A.

首页> 外文期刊>European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) >Costimulatory T-cell engagement by PRS-343, a CD137 (4-1BB)/HER2 bispecific, leads to tumor growth inhibition and TIL expansion in a humanized mouse model

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Costimulatory T-cell engagement by PRS-343, a CD137 (4-1BB)/HER2 bispecific, leads to tumor growth inhibition and TIL expansion in a humanized mouse model

机译：PRS-343的性交T细胞接合，CD137（4-1BB）/ HER2双特异性导致人源化小鼠模型中的肿瘤生长抑制和直到膨胀

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《European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) 》 |2016年第null期| 共1页
作者
Hinner M. J.; Aiba R. S. Bel; Schlosser C.; Jaquin T.; Allersdorfer A.; Berger S.; Wiedenmann A.; Matschiner G.; Schueler J.; Moebius U.; Rothe C.; Olwill S. A.;
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Pieris Pharmaceut GmbH Immunooncol Freising Weihenstephan Germany;

Pieris Pharmaceut GmbH Immunooncol Freising Weihenstephan Germany;

Pieris Pharmaceut GmbH Immunooncol Freising Weihenstephan Germany;

Pieris Pharmaceut GmbH Immunooncol Freising Weihenstephan Germany;

Pieris Pharmaceut GmbH Immunooncol Freising Weihenstephan Germany;

Pieris Pharmaceut GmbH Immunooncol Freising Weihenstephan Germany;

Pieris Pharmaceut GmbH Immunooncol Freising Weihenstephan Germany;

Pieris Pharmaceut GmbH Immunooncol Freising Weihenstephan Germany;

Oncotest GmbH In Vivo Operat Freiburg Germany;

Pieris Pharmaceut GmbH Immunooncol Freising Weihenstephan Germany;

Pieris Pharmaceut GmbH Immunooncol Freising Weihenstephan Germany;

Pieris Pharmaceut GmbH Immunooncol Freising Weihenstephan Germany;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学 ;
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1. Costimulatory T-cell engagement by PRS-343, a CD137 (4-1BB)/HER2 bispecific, leads to tumor growth inhibition and TIL expansion in a humanized mouse model [J] . Hinner M. J., Aiba R. S. Bel, Schlosser C., European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2016 ,第Null期

机译：CD137（4-1BB）/ HER2双特异性PRS-343对T细胞的共刺激作用在人源化小鼠模型中导致肿瘤生长抑制和TIL扩展
2. Costimulatory T-cell engagement by PRS-343, a CD137 (4-1BB)/HER2 bispecific, leads to tumor growth inhibition and TIL expansion in a humanized mouse model [J] . Hinner M. J., Aiba R. S. Bel, Schlosser C., European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2016 ,第Null期

机译：PRS-343的性交T细胞接合，CD137（4-1BB）/ HER2双特异性导致人源化小鼠模型中的肿瘤生长抑制和直到膨胀
3. Tumor-Localized Costimulatory T-Cell Engagement by the 4-1BB/HER2 Bispecific Antibody-Anticalin Fusion PRS-343 [J] . Hinner Marlon J., Aiba Rachida Siham Bel, Jaquin Thomas J., Clinical cancer research: an official journal of the American Association for Cancer Research . 2019 ,第19期

机译：肿瘤局部化的刺激性T细胞接合4-1BB / HER2双特异性抗体 - 抗氨基融合PRS-343
4. Photodynamic therapy stimulates anti-tumor immune response in mouse models: the role of regulatory T-cells, anti-tumor antibodies, and immune attack on brain metastases [C] . Fatma Vatansever, Masayoshi Kawakubo, Hoon Chung, Biophotonics and immune responses VIII . 2013

机译：光动力疗法在小鼠模型中刺激抗肿瘤免疫反应：调节性T细胞，抗肿瘤抗体的作用以及对脑转移瘤的免疫攻击
5. Loss of HdmX leads to alterations in gene expression and inhibition of cell growth in tumor cells with wild-type p53. [D] . Heminger, Katherine Ann. 2007

机译：HdmX的丧失导致野生型p53肿瘤细胞中基因表达的改变和细胞生长的抑制。
6. Co-Stimulation through 4-1BB/CD137 Improves the Expansion and Function of CD8+ Melanoma Tumor-Infiltrating Lymphocytes for Adoptive T-Cell Therapy [O] . Jessica Ann Chacon, Richard C. Wu, Pariya Sukhumalchandra, -1

机译：通过4-1BB / CD137的共同刺激可改善CD8 +黑色素瘤肿瘤浸润淋巴细胞的扩展和功能以进行过继T细胞治疗
7. Co-stimulation through 4-1BB/CD137 improves the expansion and function of CD8(+) melanoma tumor-infiltrating lymphocytes for adoptive T-cell therapy. [O] . Jessica Ann Chacon, Richard C Wu, Pariya Sukhumalchandra, 2013

机译：通过4-1BB / CD137的共刺激改善CD8（+）黑素瘤肿瘤浸润淋巴细胞的过度T细胞疗法的扩增和功能。

Costimulatory T-cell engagement by PRS-343, a CD137 (4-1BB)/HER2 bispecific, leads to tumor growth inhibition and TIL expansion in a humanized mouse model

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