Severe xanthomatosis with prominent tuberous xanthomas on the cheeks and the nasal dorsum in a patient with type IIa hyperlipoproteinemia

摘要

Several clinical forms of xanthoma exist: plane xanthoma, which includes xanthoma palpebraram (xanthelasma) and palmar striae; tuberous xanthoma; eruptive xanthoma and tendinous xanthoma [1,2]. Tuberous xanthomas most commonly develop on the elbows, knees, fingers and buttocks [1,2], but there are no reports of facial tuberous xanthomas. Here, we describe a patient with severe xanthomatosis in the setting of type IIa hyperlipoproteinemia, with prominent tuberous xanthomas on the cheeks and nasal dorsum. A 52-year-old Japanese woman presented with a 5-year history of multiple asymptomatic, gradually growing, subcutaneous lesions on her face, elbows, knees, fingers and toes. Five days previously, xanthoma palpebramm had been removed from the upper eyelids and left lateral angle of the eye by a plastic surgeon.