P-076: Opioid use after hospital care due to a hip fracture among community-dwelling persons with and without Alzheimer's disease

摘要

Introduction: Hip fractures are common among persons with Alzheimer's disease (AD), but problems in pain assessment may lead to insufficient analgesia after hospitalization. Methods: We investigated the prevalence of opioid use during 6 months after discharge from hospital care due to a hip fracture among community-dwellers with and without AD. The Medication use and Alzheimer's disease (MEDALZ) cohort was used for this study, consisting of all community-dwelling persons newly diagnosed with AD during 2005-2011 in Finland. Persons with AD were matched with comparison persons without AD on age, sex and region of residence at the time of AD diagnosis. Data were collected from nationwide health care registers. Results: Altogether 2342 persons with AD and 1615 persons without AD, discharged to community settings within B 120 days after a hip fracture were included. A higher percentage of persons with AD used opioids during 6 months after discharge compared to those without AD, 39.5% (95% confidence interval, CI, 37.5-41.5) vs. 31.2% (95% CI 28.9-33.5). Persons with AD used more frequently strong opioids during the first 3 months, buprenorphine during 6 months, and weak opioids less frequently after the first month after discharge compared to those without AD. Key conclusions: Frequent opioid use after hospital care due to hip fractures may indicate increased attention to pain among persons with AD. Nevertheless, benefits and harms of opioid use should be evaluated regularly in community-dwelling older persons, both with and without AD.