Metagenome analysis of Russian and Georgian Pyophage cocktails and a placebo‐controlled safety trial of single phage versus phage cocktail in healthy        <i xmlns='http://www.wiley.com/namespaces/wiley'>Staphylococcus aureusStaphylococcus aureus        carriers

McCallin Shawna; Sarker Shafiqul A.; Sultana Shamima; Oechslin Frank; Brüssow Harald

摘要

Summary > Bacteriophage therapy is a commonly used treatment for Staphylococcus aureus infections in countries of the former Soviet Union, using both single phages and phage cocktails. The scarce data available on Eastern phage cocktails prompted an investigation into commercially‐available Pyophage cocktails from two different manufacturers used to treat skin and wound infections. Comparison of the metagenomic composition of two Pyophage products from Georgia and Russia revealed substantial differences in phage‐types targeting Escherichia, Enterococcus, Salmonella, Pseudomonas aeruginosa and Proteus , therefore indicating multiple strategies for composing phage cocktails against these bacterial pathogens. Closely‐related Kayvirus‐like Myoviruses were, however, a shared component against S. aureus within all products, except for the inclusion of a secondary S. aureus Podovirus in one Microgen cocktail. Metagenomic analysis also revealed the presence of several probable prophage sequences but detected no genetic safety risks in terms of virulence factors or antibiotic resistance genes. The safety of broad‐spectrum cocktails was tested by comparing the effects of nasal and oral exposure to Eliava Pyophage, a monospecies counterpart and placebo in healthy human carriers of S. aureus. The lack of adverse effects in any treatment groups supports the clinical safety of S. aureus phages administered as a single phage or as phage cocktail. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract XMLNS =“http://www.wiley.com/namespaces/wiley”type =“main”xml：lang =“en”> <标题类型=“main”>摘要</ title> >噬菌体治疗是使用单噬菌体和噬菌体鸡尾酒的前苏联国家的常用治疗A>金黄色葡萄球菌感染。东部噬菌体鸡尾酒上可用的稀缺数据促进了从两种不同制造商的商业上可用的Pyophage鸡尾酒调查，用于治疗皮肤和伤口感染。来自格鲁吉亚和俄罗斯的两种PYOPHAGE产品的比较术语术语靶向靶向的显着差异 eNTcherichia，肠球菌，沙门氏菌，假单胞菌铜绿假单胞菌和蛋白质</ i>，因此表明多种策略用于对这些细菌病原体进行噬菌体鸡尾酒。然而，与密切相关的Kayvirus的神经病毒是对的共用组分。所有产品中的金黄色葡萄球菌</ i>除了包含二级。金黄色葡萄球菌</ i> Podovirus在一个微鸡尾酒中。 Metagenomic分析还揭示了几种可能的预知序列的存在，但在毒力因子或抗生素抗性基因方面没有检测到遗传安全风险。通过比较鼻和口服暴露于Eliava Pophage的影响，通过在 S的健康人载体中的单体对应和安慰剂来测试广谱鸡尾酒的安全性。金黄色葡萄球菌。</ i>在任何治疗组中缺乏不利影响支持 s的临床安全性。 AUREUS </ i>噬菌体作为单噬菌体或噬菌体鸡尾酒施用。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-22868/'>《Environmental microbiology》</a> <b style="margin: 0 2px;">|</b><span>2018年第9期</span><b style="margin: 0 2px;">|</b><span>共16页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=McCallin Shawna&option=202" target="_blank" rel="nofollow">McCallin Shawna;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sarker Shafiqul A.&option=202" target="_blank" rel="nofollow">Sarker Shafiqul A.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sultana Shamima&option=202" target="_blank" rel="nofollow">Sultana Shamima;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Oechslin Frank&option=202" target="_blank" rel="nofollow">Oechslin Frank;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Brüssow Harald&option=202" target="_blank" rel="nofollow">Brüssow Harald;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Fundamental MicrobiologyUniversity of LausanneLausanne Switzerland;</p> <p>International Centre for Diarrhoeal Diseases Research Bangladesh (icddr b)Dhaka Bangladesh;</p> <p>International Centre for Diarrhoeal Diseases Research Bangladesh (icddr b)Dhaka Bangladesh;</p> <p>Department of Fundamental MicrobiologyUniversity of LausanneLausanne Switzerland;</p> <p>Laboratory of Gene TechnologyDepartment of Biosystems KU LeuvenLeuven Belgium;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/183.html" title="微生物学">微生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> </p> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a 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Metagenome analysis of Russian and Georgian Pyophage cocktails and a placebo‐controlled safety trial of single phage versus phage cocktail in healthy Staphylococcus aureusStaphylococcus aureus carriers

摘要