<i xmlns='http://www.wiley.com/namespaces/wiley'>Into the stormInto the storm : Chasing the opportunistic pathogen <i xmlns='http://www.wiley.com/namespaces/wiley'>Staphylococcus aureusStaphylococcus aureus from skin colonisation to life‐threatening infections

OGara James P.

摘要

Summary > Colonisation of the human skin by Staphylococcus aureus is a precursor for a variety of infections ranging from boils to sepsis and pneumonia. The rapid emergence of methicillin‐resistant S. aureus following the clinical introduction of this antimicrobial drug and reports of resistance to all currently used anti‐staphylococcal drugs has added to its formidable reputation. S. aureus survival on the?skin and in vivo virulence is underpinned by a remarkable environmental adaptability, made possible by highly orchestrated regulation of gene expression and a capacity to undertake genome remodelling. Depending on the ecological or infection niche, controlled expression of a variety of adhesins can be initiated to facilitate adherence to extracellular matrix proteins, survival against desiccation or biofilm accumulation on implanted medical devices and host tissue. These adherence mechanisms complement toxin and enzyme production, immune evasion strategies, and antibiotic resistance and tolerance to collectively thwart efforts to develop reliable antimicrobial drug regimens and an effective S. aureus vaccine. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract xmlns =“http://www.wiley.com/namespaces/wiley”type =“main”> <title type =“main”>摘要</ title> >人类皮肤的定位金葡萄球菌aureus </ i>是一种从脓毒和肺炎的各种感染的前体。耐甲氧脲抗性的快速出现。金黄色葡萄球菌临床引入这种抗菌药物和对目前使用目前使用的抗葡萄球菌药物的抗性报告增加了其强大的声誉。 s。 AUREUS </ i>在体内生存和生存在体内和毒力的毒力是通过显着的环境适应性基础，通过高度衡量的基因表达调节和进行基因组重塑的能力来实现。取决于生态或感染乳蛋白的生态学或感染性，可以启动各种粘附素的受控表达，以促进粘附细胞外基质蛋白，对植入的医疗装置和宿主组织的消除或生物膜积累。这些粘附机制补充毒素和酶生产，免疫逃避策略和抗生素抗性和耐受性，以统称为开发可靠的抗微生物药物方案和有效的。金黄色葡萄球菌</ i>疫苗。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-22868/'>《Environmental microbiology》</a> <b style="margin: 0 2px;">|</b><span>2017年第10期</span><b style="margin: 0 2px;">|</b><span>共11页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=OGara James P.&option=202" target="_blank" rel="nofollow">OGara James P.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of MicrobiologySchool of Natural Sciences National University of IrelandGalway Ireland;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/183.html" title="微生物学">微生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> </p> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" 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Into the stormInto the storm : Chasing the opportunistic pathogen Staphylococcus aureusStaphylococcus aureus from skin colonisation to life‐threatening infections

摘要