The effect of vitamin D-3 and paricalcitol on penicillin-induced epileptiform activity in rats

摘要

Aim: Epilepsy is a disease characterized by seizures which impair human life considerably. Vitamin D is of different systemic effects on metabolism and its deficiency is known to have a high prevalence among epilepsy patients. Paricalcitol, a vitamin D receptor agonist, has relatively fewer side effects. This study aimed to investigate the anticonvulsant effect of vitamin D-3 (cholecalciferol) and paricalcitol on penicillin-induced epileptiform activity.