Evidences on the role of the lid loop of gamma-glutamyltransferases (GGT) in substrate selection

摘要

gamma-Glutamyltransferase (GGT) catalyzes the transfer of the gamma-glutamyl moiety from a donor substrate such as glutathione to water (hydrolysis) or to an acceptor amino acid (transpeptidation) through the formation of a gamma-glutamyl enzyme intermediate.