Probiotics Efficacy on Oxidative Stress Values in Inflammatory Bowel Disease: A Randomized Double-Blinded Placebo-Controlled Pilot Study

摘要

Background: Inflammatory bowel diseases (IBD), which include Crohn’s disease (CD) andulcerative colitis (UC), are described as a chronic inflammation of the small intestine and colon, causedby a dysregulated immune response to host intestinal microbiota in genetically susceptible subjects.Objective: The aim of this study was to compare probiotic therapy versus placebo in Oxidative StressValues and clinical features in patients affected by IBD.Method: Forty (40) patients previously diagnosed for IBD were recruited and randomized to receiveprobiotics (test group, n=20) or placebo (control group, n=20) administered for 90 days. Subjects inboth the groups were assessed for overall oxidant ability (d-ROMs test) and for the antioxidant response(BAP test): data were reported at baseline, after 1 and 3 months. Additional data from anamnesisand haematological investigation were also reported during the study.Results: d-ROM assay clearly showed that the values observed in the test group were significantlyimproved, leading to oxidative stress values which are not pathological. The test group showed increasingBAP values, thus confirming the overall improvements of patients ‘health following administrationof probiotics.Conclusion: Oral administration of the specific probiotics demonstrated its efficacy and safety on patientsaffected by IBD.