Safety Assessment of Silylates and Surface-Modified Siloxysilicates

摘要

The Cosmetic Ingredient Review (CIR) Expert Panel assessed the safety of silica silylate, silica dimethyl silylate, trimethylsilox-ysilicate, and trifluoropropyldimethyl/trimethylsiloxysilicate as used in cosmetics. These silylates and surface-modified siloxysilicates function in cosmetics as antifoaming agents, anticaking agents, bulking agents, binders, skin-conditioning agents-emollient, skin-conditioning agents-occlusive, slip modifiers, suspension agents-nonsurfactant, and viscosity increasing agents-nonaqu-eous. The Expert Panel reviewed the available animal and clinical data as well as information from a previous CIR safety assessment of amorphous silica. The CIR Expert Panel concluded that silica silylate, silica dimethyl silylate, trimethylsiloxysilicate, and trifluoropropyldimethyl/trimethylsiloxysilicate are safe *as used when formulated and delivered in the final product not to be irritating or sensitizing to the respiratory tract.