Preparation and properties of BMPLGA/NBAG-beta-TCP composite scaffold materials

摘要

Biodegradable polymer/bioceramic composite scaffolds can overcome the limitations of conventional ceramic bone substitutes such as brittleness and difficulty in shaping. A novel degradable scaffold material for bone tissue repairing was developed by combining 1,4-butanediamin-modified poly(lactide-co-glycolide) (BMPLGA) with nano-biaoactive glass and nano-beta-tricalcium phosphate (NBAG-beta-TCP) . The effects of the inorganic filler content on the morphology, water adsorption, and compressive strength of the nanocomposite scaffolds were investigated. The nanocomposite scaffolds showed an interconnected pore structure with the pore size ranging from 50 to 200 mu m. The compressive strength and the water adsorption ability were enhanced with increasing content of the inorganic fillers. The cell proliferation of fibroblast was significantly improved after three and seven days of culture on BMPLGA/NBAG-beta-TCP films in comparison with BMPLGA films. The BMPLGA/NBAG-beta-TCP composites have a wide application as a potential biomaterial in medical field.