Synthesis and characterization of(2E)-1-[(6-nitro-1,3-benzoxazol-2-yl) sulfanyl]propan-2-one iV-[(lZ)-(4-chlorophenyl) methylidene] thiosemicarbazone Benzoxazole Derivatives and their biological Activities

摘要

In this study a new series of(2E)-1-[(6-nitro-1,3-benzoxazol-2-yl)sulfanyl]propan-2-one N-[(1Z)-(4-chloroyphenyl)methylidene]thiosemicarbazone derivatives have been synthesized by standard physicochemical methods.The structures of newly synthesized benzoxazole derivatives(5_(a-f)) were characterized by elemental analysis,FT-IR,~1H NMR,~(13)C NMR and mass spectral studies.The synthesized compounds(5_(a-f)) has been screened for their antimicrobial activity using the disc diffusion and minimum inhibitory concentration(MIC) method against the selected bacterias(Staphylococcus aureus,Staphylococcus epidemidis,Bacillus subtilis,P.aeruginosa,Vibrio cholerae and E.coli) and fungal strain(Aspergillus aureus and Aspergillus fumigates).Among all synthesized benzoxazole derivatives 5b,5c,5d and 5f were found to be more potent antibacterial active against all tested strains.The In vitro antimicrobial activity at MIC level showed that the compound 5a also exhibit potent antimicrobial activity as similar to compound 5c.The antioxidant properties were evaluated by 2,2-diphenyl-1-picrylhydrazyl(DPPH) scavenging method.Compounds 5a and 5b showed predominant antioxidant activities among the synthesized analogues.