Can Lipid Profile Estimation in Early Second Trimester be a Predictor of Pregnancy Induced Hypertension?

摘要

INTRODUCTION: Hypertension complicates 5-10% of all pregnancies. It can be just a sign of underlying pathology which maybe either pre-existing or appear for the first time during pregnancy, it is characterized by widespread endotheliai damage which originates from uteroplacental circulation and involves other organs such as kidney, liver, brain etc. Hypertensive disorders of pregnancy carry risk both for the mother and baby. Besides, pregnancy has been found to be associated with changes in lipid profile and this differs with each trimester. There is progressive increase in concentration of total cholesterol, tri-glyceride, LDL, VLDL and slight decrease in HDL cholesterol during the course of pregnancy. These changes ensure a continuous supply of nutrients to the developing foetus in addition to increased demand of pregnant mother. Correlation between serum lipid ievels and gestational hypertension has been suggested by several authors in the past. An abnormal lipid profile has a direct effect on endothelial dysfunction, In view of these findings, this study was undertaken to identify women at risk of pregnancy induced hypertension so that timely preventive management can be done.