Antioxidant Effect of Aqueous Extract of Cynodon Dactylon in Streptozotocin Diabetic Rats

摘要

Background: Cynodon dactylon L. pers is one of the plants with applied medicinal value. This study aimed to examine the effect of C. dactylon (L.) aqueous extract on Malondialdehyde (MDA) levels and catalase (CAT) activity in liver and kidney of diabetic rats. Materials and Methods: In this experimental study, 30 adult male rats were divided into five groups (n=6). Control rats were injected with physiological saline and the others were made diabetic by the injection of streptozotocin (STZ; 70 mg/kg, i.p.). The third, fourth and fifth diabetic groups were given the oral aqueous extract of C. dactylon at different doses (50, 250 and 500 mg/kg) for 4 weeks. At the end of the study, blood glucose, MDA concentration and CAT activities of kidney and liver tissues were determined. Results: The activity of CAT of diabetic rats treated with the 500 mg/kg extract was increased significantly compared to the untreated diabetic rats (P<0.05). Treatment with extract resulted in reduction of MDA in comparison to diabetic group. Conclusion: Aqueous extract of C. dactylon (L.) could be effective in decreasing diabetic complication and this effect is attributed to the antioxidant activity of the plant