Synthesis of new scaffolds of isoxazolidine derivatives from dihydrofuran via 1,3-dipolar cycloaddition reactions under solvent free conditions

摘要

Synthesis of a new class of isoxazolidine derivatives have been reported from dihydrofuran under solvent free conditions via 1,3-dipolar cycloaddition reactions. The new cycloadducts have been found to have good synthetic potentiality as they could be easily functionalized into 1,3-amino alcohols. High selectivity, good to excellent yields, greener approach and good synthetic potentiality are the important features in these syntheses.