Stereoselective epoxidation of aziridin-2-acrylaldehydes and azirinols synthesized from epoxyaldehydes catalyzed by NHC catalyst

摘要

Chiral aziridine-epoxyaldehydes (d.r. up to 99:1) have been obtained from stereoselective epoxidation of aziridin-2-acrylaldehyde in the presence of proline-derivatived catalyst. The desired aziridine-epoxyaldehydes can give valuable azirinols via ring opening reaction catalyzed by NBC catalyst. These azirinol derivatives are good candidates for the synthesis of more functionalized structures.