Oral Complications of Multiorgan Disorders

摘要

Amyloidosis represents a group of acquired or hereditary diseases involving a systemic or localized accumulation of insoluble fibrillar proteins. Modern classification uses an abbreviation of the protein that composes most deposits, prefixed by the letter "A." AL amyloidosis, for example, the most common form of the disease, is caused by deposition of protein derived from immunoglobulin light chain fragments. AL amyloidosis can occur alone or in association with multiple myeloma, Waldenstrom macroglobulinemia, or non-Hodgkin lymphoma. AA (serum amyloid A protein) amyloidosis may complicate chronic diseases, such as rheumatoid arthritis or inflammatory bowel disease. Dialysis-related amyloidosis (Ap2-microglobulin) may be seen in those on long-term dialysis. Transthyretin-related amyloidosis (ATTR) is a hereditary form. Alzheimer disease and orofacial amyloidosis are examples of localized amyloidoses.