IR resonance-enhanced organic detection with two-step laser desorption time-of-flight mass spectrometry

摘要

Highlights?We characterize the resonance-enhanced desorption of analyte with a two-step laser desorption time-of-flight mass spectrometer.?Desorption of trace organic species may be increased by coupling the wavelength of the desorption laser to vibration transitions of minerals or organic functional groups.?Resonance-enhanced L2MS is well-suited for the detection of unknown analyte in mineral matrices while minimizing IR laser power.AbstractWe explore resonance-enhanced sample analysis with a prototype two-step laser desorption time-of-flight mass spectrometer (L2MS) to characterize the dependence of resonant desorption on the L2MS detection sensitivity. In L2MS, desorption and ionization of analyte is separated into two distinct steps: an IR laser desorbs surface material and a UV laser ionizes analyte from the resulting neutral plume. Desorption of analyte, including trace organic species, may be increased by coupling the wavelength of the desorption laser to IR absorpti