Three-Component Regioselective Synthesis of Tetrahydrofuro[2,3-d] oxazoles and Their Efficient Conversion to Oxazoles

摘要

Iodosylbenzene with triflimide (Tf2NH) efficiently promotes a three-component regioselective synthesis of tetrahydrofuro[2,3-d] oxazoles from homopropargyl alcohols, benzonitrile, and O atoms via oxidative [2+ 2+ 1] annulations induced by iodocyclization of the homopropargyl alcohols. In addition, the resulting bicyclic compounds can be converted into 2,4,5-trisubstituted oxazoles bearing hydroxy groups quantitatively; these oxazole derivatives are cores of PPAR agonist analogues.