Topical application of phenytoin or nifedipine-loaded PLGA microspheres promotes periodontal regeneration in vivo

摘要

Objectives: Gingival recession and alveolar bone loss are common manifestations of periodontitis. Periodontal regeneration is the ideal strategy for rehabilitating periodontal tissue defects and preventing tooth loss. The present study examined whether localized, topical application of gingival overgrowth-inducing drugs, phenytoin nifedipine or cyclosporine induces periodontal regeneration.