Tyrosine kinase Fyn promotes osteoarthritis by activating the -catenin pathway

Li Kai; Zhang Yue; Zhang Yuwei; Jiang Wenqing; Shen Junhui; Xu Song; Cai Daozhang; Shen Jie; Huang Bin; Li Mangmang; Song Qiancheng; Jiang Yu; Liu Anling; Bai Xiaochun

首页> 外文期刊>Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research >Tyrosine kinase Fyn promotes osteoarthritis by activating the -catenin pathway

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Tyrosine kinase Fyn promotes osteoarthritis by activating the -catenin pathway

机译：酪氨酸激酶Fyn通过激活-catenin途径来促进骨关节炎

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Objectives To investigate the role of tyrosine kinase Fyn in the development of osteoarthritis (OA) and the underlying mechanisms, and to define whether targeting Fyn could prevent OA in mice.

机译：目的探讨酪氨酸激酶FIN在骨关节炎（OA）和潜在机制的发展中的作用，并定义靶向FYN是否可以防止老鼠中的OA。

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来源
《Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research》 |2018年第6期|共9页
作者
Li Kai; Zhang Yue; Zhang Yuwei; Jiang Wenqing; Shen Junhui; Xu Song; Cai Daozhang; Shen Jie; Huang Bin; Li Mangmang; Song Qiancheng; Jiang Yu; Liu Anling; Bai Xiaochun;
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作者单位

Southern Med Univ Affiliated Hosp 3 Acad Orthoped Guangzhou 510515 Guangdong Peoples R China;

Southern Med Univ Sch Basic Med Sci Dept Cell Biol State Key Lab Organ Failure Res Guangzhou;

Southern Med Univ Sch Basic Med Sci Dept Cell Biol State Key Lab Organ Failure Res Guangzhou;

Southern Med Univ Sch Basic Med Sci Dept Cell Biol State Key Lab Organ Failure Res Guangzhou;

Southern Med Univ Sch Basic Med Sci Dept Cell Biol State Key Lab Organ Failure Res Guangzhou;

Southern Med Univ Nanfang Hosp Dept Orthoped &

Arthroplasty Guangzhou Guangdong Peoples R China;

Southern Med Univ Affiliated Hosp 3 Acad Orthoped Guangzhou 510515 Guangdong Peoples R China;

Southern Med Univ Affiliated Hosp 3 Acad Orthoped Guangzhou 510515 Guangdong Peoples R China;

Southern Med Univ Affiliated Hosp 3 Acad Orthoped Guangzhou 510515 Guangdong Peoples R China;

Southern Med Univ Sch Basic Med Sci Dept Cell Biol State Key Lab Organ Failure Res Guangzhou;

Southern Med Univ Sch Basic Med Sci Dept Cell Biol State Key Lab Organ Failure Res Guangzhou;

Univ Pittsburgh Sch Med Dept Pharmacol &

Chem Biol Pittsburgh PA USA;

Southern Med Univ Sch Basic Med Sci Dept Cell Biol State Key Lab Organ Failure Res Guangzhou;

Southern Med Univ Affiliated Hosp 3 Acad Orthoped Guangzhou 510515 Guangdong Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类免疫性疾病;
关键词
chondrocytes; osteoarthritis; knee osteoarthritis;

机译：软骨细胞;骨关节炎;膝关节骨关节炎;

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专利

1. Tyrosine kinase Fyn promotes osteoarthritis by activating the -catenin pathway [J] . Li Kai, Zhang Yue, Zhang Yuwei, Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2018,第6期

机译：酪氨酸激酶Fyn通过激活-catenin途径来促进骨关节炎
2. Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival. [J] . Tang X, Feng Y, Ye K Cell death and differentiation . 2007,第2期

机译：Src家族酪氨酸激酶Fyn磷酸化磷脂酰肌醇3激酶增强剂激活Akt，防止其凋亡裂解并促进细胞存活。
3. Activation of TrkA tyrosine kinase in embryonal carcinoma cells promotes cell compaction, independently of tyrosine phosphorylation of catenins [J] . Cozzolino M., Serafino A., Knudsen K., Journal of Cell Science . 2000,第9期

机译：TrkA酪氨酸激酶在胚胎癌细胞中的激活促进细胞紧实，独立于连环蛋白的酪氨酸磷酸化
4. A key tryptophan in the Tec-family tyrosine kinase Btk allosterically regulates kinase activation [C] . Thomas E. Wales, Raji E. Joseph, Amy H. Andreotti, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：TEC-Family酪氨酸激酶BTK中的一个关键色氨酸构成调节激酶活化
5. Modulation of the neuronal voltage-gated sodium channel Nav1.2 by the non-receptor tyrosine kinase Fyn. [D] . Ahn, Misol. 2007

机译：非受体酪氨酸激酶Fyn对神经元电压门控钠通道Nav1.2的调节。
6. Circular RNA Protein Tyrosine Kinase 2 Promotes Cell Proliferation Migration and Suppresses Apoptosis via Activating MicroRNA-638 Mediated MEK/ERK WNT/β-Catenin Signaling Pathways in Multiple Myeloma [O] . Fan Zhou, Dongjiao Wang, Nian Zhou, 2021

机译：圆形RNA蛋白酪氨酸激酶2通过激活MicroRNA-638介导的MEK / ERKWNT /β-Catenin信号传导途径促进细胞增殖迁移和抑制细胞凋亡在多发性骨髓瘤中
7. p120 Catenin-associated Fer and Fyn tyrosine kinases regulate β-catenin Tyr-142 phosphorylation and β-catenin-α-catenin interaction [O] . Piedra, Jose, Pálmer, Héctor G., García de Herreros, Antonio, 2013

机译：p120连环蛋白相关的Fer和Fyn酪氨酸激酶调节β-cateninTyr-142磷酸化和β-catenin-α-catenin相互作用
8. DMBA induces tyrosine phosphorylation of PLC-(gamma)1 and activates the tyrosine kinases lck and fyn in the HPB-ALL human T-cell line [R] . Archuleta, M M, Schieven, G L, Ledbetter, JA, 1993

机译：DmBa诱导pLC-（γ）1的酪氨酸磷酸化并激活HpB-aLL人T细胞系中的酪氨酸激酶lck和fyn。

Tyrosine kinase Fyn promotes osteoarthritis by activating the -catenin pathway

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