Effect on efficacy and safety trial outcomes of also enrolling patients on ongoing glucocorticoid therapy in rheumatoid arthritis clinical trials of tocilizumab or adalimumab or methotrexate monotherapy

Safy-Khan Mary; Jacobs Johannes W. G.; de Hair Maria J. H.; Welsing Paco M. J.; Edwardes Michael D.; Teitsma Xavier M.; Luder Yves; Devenport Jenny; van Laar Jacob M.; Pethoe-Schramm Attila; Bijlsma Johannes W. J.

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Effect on efficacy and safety trial outcomes of also enrolling patients on ongoing glucocorticoid therapy in rheumatoid arthritis clinical trials of tocilizumab or adalimumab or methotrexate monotherapy

机译：对持续糖皮质激素治疗的患者患者疗效和安全试验结果的影响与过普利单抗或甲氨蝶呤或甲氨蝶呤单药治疗的临床试验

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Background

机译：背景

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来源
《Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research》 |2020年第4期|共4页
作者
Safy-Khan Mary; Jacobs Johannes W. G.; de Hair Maria J. H.; Welsing Paco M. J.; Edwardes Michael D.; Teitsma Xavier M.; Luder Yves; Devenport Jenny; van Laar Jacob M.; Pethoe-Schramm Attila; Bijlsma Johannes W. J.;
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作者单位

UMC Utrecht Dept Rheumatol &

Clin Immunol Utrecht Netherlands;

UMC Utrecht Dept Rheumatol &

Clin Immunol Utrecht Netherlands;

Novartis Pharma BV Amsterdam Netherlands;

UMC Utrecht Dept Rheumatol &

Clin Immunol Utrecht Netherlands;

Everest Clin Res Canada Markham ON Canada;

F Hoffmann La Roche &

Cie AG Basel Switzerland;

F Hoffmann La Roche &

Cie AG Basel Switzerland;

UMC Utrecht Dept Rheumatol &

Clin Immunol Utrecht Netherlands;

F Hoffmann La Roche &

Cie AG Basel Switzerland;

UMC Utrecht Dept Rheumatol &

Clin Immunol Utrecht Netherlands;

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原文格式 PDF
正文语种 eng
中图分类免疫性疾病;
关键词
rheumatoid arthritis; DMARDs (biologic); corticosteroids; outcomes research;

机译：类风湿性关节炎;DMARDS（生物学）;皮质类固醇;结果研究;

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专利

1. Effect on efficacy and safety trial outcomes of also enrolling patients on ongoing glucocorticoid therapy in rheumatoid arthritis clinical trials of tocilizumab or adalimumab or methotrexate monotherapy [J] . Safy-Khan Mary, Jacobs Johannes W. G., de Hair Maria J. H., Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2020,第4期

机译：对持续糖皮质激素治疗的患者患者疗效和安全试验结果的影响与过普利单抗或甲氨蝶呤或甲氨蝶呤单药治疗的临床试验
2. Tocilizumab combination therapy or monotherapy or methotrexate monotherapy in methotrexate-naive patients with early rheumatoid arthritis: 2-year clinical and radiographic results from the randomised, placebo-controlled FUNCTION trial [J] . Burmester Gerd R., Rigby William F., van Vollenhoven Ronald F., Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2017,第7期

机译：在甲氨蝶呤 - 幼稚关节炎的甲氨蝶呤 - 幼稚关节炎患者中的甲磷组合治疗或单药治疗或甲氨蝶呤单药治疗：2年临床和放射线照相结果来自随机，安慰剂控制的功能试验
3. Comparative Cost per Response for 4 Clinical Endpoints with Tocilizumab Monotherapy vs Adalimumab Monotherapy in a Head-to-Head Randomized Double-Blind Superiority Trial (ADACTA) in Patients with Rheumatoid Arthritis [J] . Jennie H. Best, Steven C. Vlad, Jinglan Pei Rheumatology and Therapy . 2020,第1期

机译：4种临床终点与黄铜单药物对类风湿性关节炎患者的头脑中的4临床单药治疗的每种临床终点的比较成本与黄铜对单体化双盲优势试验（ADACTA）
4. Poster: Classifying primary outcomes in rheumatoid arthritis: Knowledge discovery from clinical trial metadata [C] . Yuanyuan Feng, Janeja Vandana P., Yesha Yelena, IEEE International Conference on Computational Advances in Bio and Medical Sciences . 2015

机译：海报：对类风湿关节炎的主要结局进行分类：从临床试验元数据中发现知识
5. Efficacy and safety of novel collagen conduits filled with collagen filaments to treat patients with peripheral nerve injury: A multicenter, controlled, open-label clinical trial [D] . Saeki Masaomi, 佐伯将臣 2019

机译：充满胶原细丝的新型胶原蛋白导管治疗周围神经损伤患者的疗效和安全性：一项多中心，对照，开放标签的临床试验
6. Concise report: Tocilizumab combination therapy or monotherapy or methotrexate monotherapy in methotrexate-naive patients with early rheumatoid arthritis: 2-year clinical and radiographic results from the randomised placebo-controlled FUNCTION trial [O] . Gerd R Burmester, William F Rigby, Ronald F van Vollenhoven, -1

机译：简明报告：初治甲氨蝶呤的类风湿关节炎患者接受Tocilizumab联合治疗或单药治疗或甲氨蝶呤单药治疗：随机安慰剂对照FUNCTION试验的2年临床和影像学结果
7. Comparative Cost Per Response for four Clinical Outcomes of Tocilizumab Monotherapy Versus Adalimumab Monotherapy in a Head-To-Head Randomized Double-Blind Superiority Trial (ADACTA) in Patients with Rheumatoid Arthritis [O] . JH Best, J Pei 2018

机译：对类黄芩素治疗的四种临床结果对幼王随机双盲优越性试验（Adacta）的四种临床结果进行了对比较成本

Effect on efficacy and safety trial outcomes of also enrolling patients on ongoing glucocorticoid therapy in rheumatoid arthritis clinical trials of tocilizumab or adalimumab or methotrexate monotherapy

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